Results 51 to 60 of about 3,587,142 (311)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Whole genome sequencing reveals local transmission patterns of mycobacterium bovis in sympatric cattle and badger populations [PDF]

, 2012
Whole genome sequencing (WGS) technology holds great promise as a tool for the forensic epidemiology of bacterial pathogens. It is likely to be particularly useful for studying the transmission dynamics of an observed epidemic involving a largely ...
O'Hare, Anthony, Stanley McDowell, Mallon Tom, Orton, Richard, Mallon, Tom, Biek, R., O'Hare, A., Robin A. Skuce (116935), Kao, R.R., Skuce, Robin A, Tom Mallon, David Wright, Orton Richard J., Kao, Rowland R., Rowland R Kao, McCormick, Carl, Wright David, Biek Roman, Hannah Trewby (116929), Richard J. Orton (116918), Skuce Robin A., Hannah Trewby, McDowell, S., Kao Rowland R., Kao, Rowland R, Trewby, Hannah, Carl McCormick, Skuce, Robin A., Tom Mallon (116914), McCormick, C., David Wright (116911), Mallon, T., Roman Biek (21981), Roman Biek, Wright, D., McCormick Carl, Richard J Orton, McDowell, Stanley, Trewby Hannah, Orton, Richard J., Anthony O'Hare (116908), O'Hare Anthony, McDowell Stanley, Trewby, H., Robin A Skuce, Wright, David; id_orcid, Biek, Roman, Carl McCormick (116915), Stanley McDowell (116923), Wright, David, Orton, R.J., Rowland R. Kao (116940), Skuce, R.A., Anthony O'Hare   +53 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Bioinformatic analysis of Mycobacterium tuberculosis whole genome data [PDF]

Tuberculosis (TB) caused by bacteria of the Mycobacterium- tuberculosis complex (MTBC) is the second major cause of death from an infectious disease worldwide.
Coll I Cerezo, F
core   +1 more source

Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle [PDF]

, 2015
Background Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus.
Magee, DA, Murphy, A., Lohan, AJ, Braud, Martin, Rue-Albrecht, K, Edwards, C.J., Schroeder, Steven, Park, S.D.E., Teasdale, Matthew D., McGettigan, Paul A., Mark, Donoghue, Braud, M, Murphy, Alison, Chamberlain, AT, Bradley, D.G., Chamberlain, Andrew, Liu, Yuan, McGettigan, PA, Lohan, A.J., Spillane, C, Magee, David A., Sonstegard, Tad S., Tai, S, Liu, Y, MacHugh, DE, Murphy, A, School of Earth and Environmental Sciences, Schroeder, S, Tai, Shuaishuai, Bradley, Daniel G., Spillane, Charles, Donaghue, M.T., Park, SD, Braud, M., Loftus, Brendan J., Park, Stephen D E, Chamberlain, Andrew T., Loftus, BJ, MacHugh, David E., Park, Stephen D. E., Bradley, DG, Donoghue, Mark T., Lohan, Amanda J., Teasdale, M.D., Liu, Y., McGettigan, P.A., Teasdale, MD, Magee, D.A., Sonstegard, TS, Donoghue, MT, Edwards, CJ, University of Dublin Trinity College, Rue-Albrecht, Kévin, Chamberlain, A.T., Edwards, Ceiridwen J.   +54 more
core   +1 more source

Mixed Modeling with Whole Genome Data

Journal of Probability and Statistics, 2012
Objective. We consider the need for a modeling framework for related individuals and various sources of variations. The relationships could either be among relatives in families or among unrelated individuals in a general population with cryptic ...
Jing Hua Zhao, Jian'an Luan
doaj   +1 more source

Tracking the evolution of the SARS-CoV-2 Delta variant of concern: analysis of genetic diversity and selection across the whole viral genome

Frontiers in Microbiology, 2023
BackgroundSince 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has diversified extensively, producing five highly virulent lineages designated as variants of concern (VOCs).
Katherine Li, Katherine Li, Stephanie Melnychuk, Paul Sandstrom, Paul Sandstrom, Hezhao Ji, Hezhao Ji   +6 more
doaj   +1 more source

Ancestral Genome Reconstruction on Whole Genome Level [PDF]

Current Genomics, 2017
Comparative genomics, evolutionary biology, and cancer researches require tools to elucidate the evolutionary trajectories and reconstruct the ancestral genomes. Various methods have been developed to infer the genome content and gene ordering of ancestral genomes by using such genomic structural variants.
Feng, Bing, Zhou, Lingxi, Tang, Jijun
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Construction and evaluation of a whole genome microarray of Chlamydomonas reinhardtii [PDF]

, 2011
Toepel J, Albaum S, Arvidsson S, et al. Construction and evaluation of a whole genome microarray of Chlamydomonas reinhardtii. BMC Genomics. 2011;12(1): 579.ABSTRACT: BACKGROUND: Chlamydomonas reinhardtii is widely accepted as a model organism regarding ...
La Russa, Marco, Goesmann, Alexander ; https://orcid.org/, Arvidsson, S., Toepel, Jörg, Goesmann, A., Samuel Arvidsson, La Russa, M., Marco la Russa, Kristin Rogge, Toepel Jörg, Albaum, S. P., Rogge Kristin, Alexander Goesmann, Albaum, Stefan ; https://orcid.org/, Kruse, Olaf ; https://orcid.org/, Olaf Kruse, Jörg Toepel, Arvidsson Samuel, Rogge, K., Goesmann Alexander, Albaum Stefan P, Toepel, J., Stefan P Albaum, Kruse Olaf, la Russa Marco, Albaum, S., Rogge, Kristin, Kruse, O.   +27 more
core   +2 more sources