Results 81 to 90 of about 3,587,142 (311)

Whole-genome haplotyping approaches and genomic medicine [PDF]

Genome Medicine, 2014
AbstractGenomic information reported as haplotypes rather than genotypes will be increasingly important for personalized medicine. Current technologies generate diploid sequence data that is rarely resolved into its constituent haplotypes. Furthermore, paradigms for thinking about genomic information are based on interpreting genotypes rather than ...
Glusman, Gustavo, Cox, Hannah C, Roach, Jared C   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitals [PDF]

, 2014
Objectives Staphylococcus haemolyticus is an emerging cause of nosocomial infections, primarily affecting immunocompromised patients. A comparative genomic analysis was performed on clinical S.
Kahlke, Tim, Flægstad, Trond, Jorunn Pauline Cavanagh, Matthew T. G. Holden, Tim Kahlke, Johanna U. Ericson Sollid, Holden, Matthew T G, Hjerde, Erik, Parkhill, Julian, Klingenberg, Claus, Claus Klingenberg, Cavanagh, Jorunn Pauline, Stephen D. Bentley, Erik Hjerde, Parkhill, J, Trond Flægstad, Sollid, Johanna U Ericson, Bentley, Stephen D, Julian Parkhill, Holden, Matthew T.G.   +19 more
core   +1 more source

Virological Aspects of COVID-19 in Patients with Hematological Malignancies: Duration of Viral Shedding and Genetic Analysis

Viruses
Coronavirus disease 2019 (COVID-19) has been associated with a significant fatality rate and persistent evolution in immunocompromised patients. In this prospective study, we aimed to determine the duration of excretion of severe acute respiratory ...
Asma Themlaoui, Massimo Ancora, Kais Ghedira, Yosra Mhalla, Manel Hamdoun, Maroua Bahri, Lamia Aissaoui, Raihane Ben Lakhal, Adriano Di Pasquale, Cesare Camma, Olfa Bahri   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Whole-genome-sequencing of triple negative breast cancers: a population study

, 2020
Exploring the value of WGS in clinical setting, we sequenced 254 triple negative breast cancers (TNBC) with associated treatment and outcome data collected between 2010-2015 via the population-based Sweden Cancerome Analysis Network-Breast (SCAN-B ...
Serena Nik-Zainal (3175647)
core   +1 more source

Whole genome phylogeny of Bacillus by feature frequency profiles (FFP) [PDF]

, 2015
Fifty complete Bacillus genome sequences and associated plasmids were compared using the “feature frequency profile” (FFP) method. The resulting whole-genome phylogeny supports the placement of three Bacillus species (B. thuringiensis, B. anthracis and B.
Ash, Gavin J., Wang, Aisuo
core   +1 more source

Whole-genome sequencing depth and coverage.

, 2023
A) Histogram of 1,035 whole-genome sequencing (WGS) samples from APIC and URECA by mean depth of coverage. B) Histogram of WGS samples based on proportion of genome covered at 20x, 25x, and 30x depth.
Deepa Rastogi (6635723), Dan Nicolae (32963), Selene Clay (14425315), Meyer Kattan (9443480), James E. Gern (7512719), Agustin Calatroni (14425318), Michael G. Sherenian (14425321), Andrew H. Liu (13886609), William Wentworth-Sheilds (697345), Matthew Dapas (9016484), Matthew C. Altman (4804422), William W. Busse (8189409), Patrice M. Becker (14425324), Robert A. Wood (3279096), Haejin Kim (833850), Gurjit K. Khurana Hershey (7889699), Carole Ober (259474), Emma E. Thompson (11544512), Cynthia M. Visness (5422457), Melanie Makhija (13886600), Joanne E. Sordillo (8451417), Rebecca S. Gruchalla (13886603), Leonard B. Bacharier (9443486), Diane R. Gold (11732568), Michelle A. Gill (13886606), George T. O’Connor (7782248), Daniel J. Jackson (7513151)   +26 more
core   +1 more source

Whole genome engineering by synthesis

Science China Life Sciences, 2018
Whole genome engineering is now feasible with the aid of genome editing and synthesis tools. Synthesizing a genome from scratch allows modifications of the genomic structure and function to an extent that was hitherto not possible, which will finally lead to new insights into the basic principles of life and enable valuable applications.
Luo, Zhouqing, Yang, Qing, Geng, Binan, Jiang, Shuangying, Yang, Shihui, Li, Xiaozheng, Cai, Yizhi, Dai, Junbiao   +7 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source