Results 241 to 250 of about 3,587,142 (311)

Isolation, antibiogram and whole genome sequence analysis of Pasteurella multocida type A from layer birds. [PDF]

PLoS One
Shahid MAH, Kabir A, Das S, Rahman MT, Nazir KHMNH.   +4 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Metabolites and Whole-Genome Analysis of the Lichenysin-Producing <i>Bacillus licheniformis</i> YC7. [PDF]

Foods
Liu X, Tang Z, Li H, He W, Chen Y, Guan B, Quan W.   +6 more
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Diagnosis Through Whole Genome Sequencing and Care Utilization in Children With Severe Illness.

JAMA Netw Open
Dias JML, More RP, Butler D, Brown J, French CE, Dolling H, Raymond FL, Rowitch DH, Aiken CE.   +8 more
europepmc   +1 more source

Citywide implementation of a rapid whole-genome sequencing program for critically ill pediatric patients. [PDF]

Nat Med
Rabea F, Aljasmi I, Jain R, Ramaswamy S, Taylor A, Shenbagam S, Chekroun I, Sinha S, El Naofal M, Yaslam S, Alfalasi R, Khadija S, Farag M, AlHajjaj S, Almadhoun F, Sharaf R, Khyriem C, Abulhoul H, Elabd H, Mustafa M, Almarri M, Du Plessis S, AlKhnbashi OS, Majid I, Buhumaid R, Al Suwaidi H, AlAwadhi M, AlKhayat A, Alsheikh-Ali A, Zahraa J, Shankar S, Abou Tayoun A.   +31 more
europepmc   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting. [PDF]

PLoS One
Waggle KD, Griffith MP, Rokes AB, Rangachar Srinivasa V, Nawrocki EM, Ereifej D, Patrick R, Coyle H, Chaudhary S, Raabe NJ, Shutt K, Sundermann AJ, Cooper VS, Harrison LH, Pless LL.   +14 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source