Results 251 to 260 of about 3,587,142 (311)

Accelerating minimap2 for whole-genome alignment. [PDF]

Bioinformatics
Chandra G, Vasimuddin M, Misra S, Jain C.   +3 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Whole genome sequencing of measles viruses: the benefit for outbreak investigation, The Netherlands, 2013-2014. [PDF]

Virus Genes
Bodewes R, Maissan C, van de Nes-Reijnen L, Boter M, van den Boom SC, Zwagemaker F, Hahné S, Woudenberg T, Ruijs WLM, Koopmans MPG, Reusken CBEM, de Vries RD, Molenkamp R, de Swart RL, Munnink BO.   +14 more
europepmc   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Whole-genome sequencing reveals a previously unrecognized measles virus cluster in Burundi. [PDF]

PLoS One
Nzoyikorera N, Nieuwenhuijse DF, Schuele L, Nduwimana C, Ndihokubwayo A, Ihorimbere T, Niyomwungere D, Cassidy H, Boter M, Nibogora C, Molenkamp R, Niyomwungere A, Nizigiyimana D, Uwineza MN, Diawara I, Otani S, Bodewes R, Aarestrup FM, Koopmans M, Nyandwi J, Oude Munnink BB.   +20 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Surveillance of antibiotic-resistant bacteria integrating whole genome sequencing and epidemiological information - a global, systematic review, 2012-2023. [PDF]

Antimicrob Resist Infect Control
Reichert F, Perry M, Sandfort M, Haller S, Said D, Eckmanns T, McDermott K, Noake C, Wolff R, Hans JB.   +9 more
europepmc   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Whole-Genome Analysis of HEV Under Sequential Ribavirin Pressure Reveals Early Minor Variants Predicting Resistance. [PDF]

J Med Virol
Colomer-Castell S, Ibañez-Lligoña M, Campos C, Gregori J, Garcia-Cehic D, Rando-Segura A, Ferrer R, Ruzo SP, Cortese MF, Tabernero D, Vico-Romero J, Ruiz-Cobo JC, Buti M, Riveiro-Barciela M, Quer J.   +14 more
europepmc   +1 more source