Results 271 to 280 of about 3,587,142 (311)
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Prospecting whole cancer genomes
Nature Cancer, 2020A new suite of studies from the Pan Cancer Analysis of Whole Genomes (PCAWG) Consortium provides the most detailed resolution of cancer genomes to date, extending our knowledge of driver genes, mutational features, structural alterations and more. Kreisberg, Ideker, Mills and Meric-Bernstam discuss the foundational and translational insights gained ...
Jason F, Kreisberg +3 more
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2006
We have developed an array-based whole-genome genotyping (WGG) assay (Infinium) using our BeadChip platform that effectively enables unlimited multiplexing and unconstrained single nucleotide polymorphism (SNP) selection. A single tube whole-genome amplification reaction is used to amplify the genome, and loci of interest are captured by specific ...
Kevin L, Gunderson +14 more
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We have developed an array-based whole-genome genotyping (WGG) assay (Infinium) using our BeadChip platform that effectively enables unlimited multiplexing and unconstrained single nucleotide polymorphism (SNP) selection. A single tube whole-genome amplification reaction is used to amplify the genome, and loci of interest are captured by specific ...
Kevin L, Gunderson +14 more
openaire +2 more sources
2010
Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review methodologies for whole genome sequencing.
Pauline C, Ng, Ewen F, Kirkness
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Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review methodologies for whole genome sequencing.
Pauline C, Ng, Ewen F, Kirkness
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Whole-Genome Sequencing of Unculturable Bacterium Using Whole-Genome Amplification
2011More than 99% of microorganisms on the earth are unculturable with known culturing techniques. The emergence of metagenomics with high-throughput sequencing technologies has enabled researchers to capture a comprehensive view of a complex bacterial community which comprises both culturable and unculturable species.
Yuichi Hongoh, Toyoda, A.
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Whole Genome Studies of Tetrahymena
2012Within the past decade, genomic studies have emerged as essential and highly productive tools to explore the biology of Tetrahymena thermophila. The current major resources, which have been extensively mined by the research community, are the annotated macronuclear genome assembly, transcriptomic data and the databases that house this information ...
Robert S, Coyne +2 more
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Interpreting Whole-Genome Sequencing
JAMA, 2014We believe that the report of the yield and interpretability of clinical whole-genome sequencing by Dr Dewey and colleagues1 is unduly pessimistic about the present and future efficacy of this molecular genetic technology in clinical medicine. Their experience of low coverage of key disease genes, poor nucleotide-calling reproducibility, low diagnostic
Wayne W, Grody +2 more
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Proceedings of the 4th Asia-Pacific Bioinformatics Conference, 2005
An innovative new technology, optical mapping, is used to infer the genome map of the location of short sequence patterns called restriction sites. The technology, developed by David Schwartz, allows the visualization of the maps of randomly located single molecules around a million base pairs in length.
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An innovative new technology, optical mapping, is used to infer the genome map of the location of short sequence patterns called restriction sites. The technology, developed by David Schwartz, allows the visualization of the maps of randomly located single molecules around a million base pairs in length.
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Computing in Science & Engineering, 1999
Computation is integrally and powerfully involved with the DNA sequencing technology that promises to reveal the complete human DNA sequence in the next several years. After introducing the latest DNA sequencing methods, this article describes three current approaches for completing the sequencing.
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Computation is integrally and powerfully involved with the DNA sequencing technology that promises to reveal the complete human DNA sequence in the next several years. After introducing the latest DNA sequencing methods, this article describes three current approaches for completing the sequencing.
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Bioinformatics Tools for Whole Genomes
Annual Review of Genomics and Human Genetics, 2000The advent of whole-genome data resources—not only sequence but also other genome-scale data collections such as gene expression, protein interaction, and genetic variation—is having two marked, complementary effects on the relatively new discipline of bioinformatics.
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Compression of Whole Genome Alignments
IEEE Transactions on Information Theory, 2010Recent advances in DNA sequencing technology have caused an exponential growth of publicly available genomic sequence data. A particularly voluminous, frequently used static data set are whole genome alignments. The first lossless compression algorithm for such data sets based on well-established statistical evolutionary models and prediction ...
Pavol Hanus +3 more
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