Results 181 to 190 of about 155,374 (249)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Cell Type Resolved Expression of Duplicate Genes Retained From Whole Genome Duplication in Atlantic salmon. [PDF]

Genome Biol Evol
Taylor RS, Ruiz Daniels R, Macqueen DJ.
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

A chromosome-level genome assembly of the varied leaved jewelflower, Streptanthus diversifolius, reveals a recent whole genome duplication. [PDF]

G3 (Bethesda)
Davis JT, Li Q, Grassa CJ, Davis MW, Strauss SY, Gremer JR, Rieseberg LH, Maloof JN.   +7 more
europepmc   +1 more source

Evolutionary patterns and structural divergence of CENH3 in legumes: Implications for haploid induction breeding

Grassland Research, EarlyView.
From structure to application: evolutionary insights and genome editing strategies for CENH3‐mediated haploid induction in legumes. Abstract Background The centromeric histone variant CENH3 is crucial for chromosome segregation and haploid induction in plants, yet its evolutionary patterns in legumes remain poorly characterized. Methods We investigated
Jialiang Zhou, Kai Wang
wiley   +1 more source

Repeated shifts out of tropical climates preceded by whole genome duplication. [PDF]

New Phytol
Carruthers T, Gonçalves DJP, Li P, Chanderbali AS, Dick CW, Fritsch PW, Larson DA, Soltis DE, Soltis PS, Weaver WN, Smith SA.   +10 more
europepmc   +1 more source

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

The role of transposon activity in shaping <i>cis</i>-regulatory element evolution after whole-genome duplication. [PDF]

Genome Res
Monsen Ø, Grønvold L, Datsomor A, Harvey T, Kijas J, Suh A, Hvidsten TR, Sandve SR.   +7 more
europepmc   +1 more source

Polygenic risk score and prostate specific antigen predict death from prostate cancer in men with intermediate aggressive cancer

International Journal of Cancer, EarlyView.
What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago, Efthymios Ladoukakis, Dorota Scibior‐Bentkowska, Belinda Nedjai   +3 more
wiley   +1 more source

The immediate metabolomic effects of whole-genome duplication in the greater duckweed, Spirodela polyrhiza. [PDF]

Am J Bot
Wu T, Bafort Q, Mortier F, Almeida-Silva F, Natran A, Van de Peer Y.   +5 more
europepmc   +1 more source