Results 11 to 20 of about 607,594 (307)

Whole Genome Sequencing in Pharmacogenomics [PDF]

Frontiers in Pharmacology, 2015
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George P Patrinos, Theodora eKatsila
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PennCNV in whole-genome sequencing data [PDF]

BMC Bioinformatics, 2017
Background The use of high-throughput sequencing data has improved the results of genomic analysis due to the resolution of mapping algorithms. Although several tools for copy-number variation calling in whole genome sequencing have been published, the ...
Leandro de Araújo Lima, Kai Wang
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Whole genome sequencing in clinical practice

BMC Medical Genomics
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of actionable cancer drivers.
Frederik Otzen Bagger, Line Borgwardt, Andreas Sand Jespersen, Anna Reimer Hansen, Birgitte Bertelsen, Miyako Kodama, Finn Cilius Nielsen   +6 more
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Whole-genome sequencing [PDF]

Practical Neurology, 2021
The costs of whole-genome sequencing have rapidly decreased, and it is being increasingly deployed in large-scale clinical research projects and introduced into routine clinical care. This will lead to rapid diagnoses for patients with genetic disease but also introduces uncertainty because of the diversity of human genomes and the potential ...
Huw R Morris, Henry Houlden, James Polke
openaire   +4 more sources

Whole Genome Sequencing in Cancer Clinics

EBioMedicine, 2015
Patients with a family history of cancer are being evaluated with single-gene or gene panel tests (LaDuca et al., 2014). The decreasing cost and potential to provide comprehensive genetic risk assessment makes whole genome sequencing (WGS) an attractive tool for understanding the genetic risk for cancer (Collins and Hamburg, 2013).
Ken Chen, Funda Meric-Bernstam
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Whole-Genome Sequencing in Cancer [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
Genome sequencing of cancer has fundamentally advanced our understanding of the underlying biology of this disease, and more recently has provided approaches to characterize and monitor tumors in the clinic, guiding and evaluating treatment. Although cancer research is relying more on whole-genome characterization, the clinical application of genomics ...
Eric Y, Zhao, Martin, Jones, Steven J M, Jones   +2 more
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Pig genome sequence - analysis and publication strategy [PDF]

, 2010
Background The pig genome is being sequenced and characterised under the auspices of the Swine Genome Sequencing Consortium. The sequencing strategy followed a hybrid approach combining hierarchical shotgun sequencing of BAC clones and whole genome ...
Fredholm, M., Harlizius Barbara, Martien A M Groenen, Bolund, Lars, Rothschild Max F, Lee Kyung-Tai, Jane Rogers, Barbara Harlizius, Denis Milan, Groenen, M.A.M., Lee, Kyung-Tai, ?, ?, Uenishi, Hirohide, Jun Wang, Uenishi Hirohide, Churcher, C., Harlizius, Barbara, Lars Bolund, Lawrence B Schook, Alan L Archibald, Archibald Alan L, Fredholm, Merete, Groenen, Martien A. M., Schook, Lawrence B., Harlizius, B., Fredholm Merete, Archibald, A.L., The Swine Genome Sequencing Consortium,, Milan Denis, Bolund Lars, Groenen, Martien A.M., Rogers Jane, Wang Jun, Swine Genome Sequencing Consortium, Hirohide Uenishi, Groenen Martien AM, Rothschild, Max F., Bolund, L., Milan, Denis, Archibald, Alan L., Wang, Jun, Merete Fredholm, Kyung-Tai Lee, The Swine Genome Sequencing Consortium, -, Carol Churcher, Rogers, Jane, Churcher, Carol, Max F Rothschild, Schook Lawrence B, Churcher Carol   +49 more
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Whole-genome sequencing confirms that Burkholderia pseudomallei multilocus sequence types common to both Cambodia and Australia are due to homoplasy [PDF]

, 2014
Whole-genome sequencing of the four isolates used in this study was supported by Wellcome Trust grant 098051, awarded to the Wellcome Trust Sanger Institute.
Theobald, V, Vandamme, P, Jacobs, J A, Vandamme, Peter, Currie, Bart J, Holden, Matthew T G, Jacobs, Jan, Jacobs, JA, Price, Erin P, Spratt, BG, Peacock, S J, Jacobs, Jan A, Parkhill, J, Holden, Matthew TG, Sarovich, DS, Sarovich, Derek S, Spratt, Brian G, Theobald, Vanessa, De Smet, B, Kham, Chun, Thong, P, Spratt, B G, Heng, Seiha, Holden, MT, Heng, S, Price, EP, Peacock, SJ, Currie, B J, Phe, Thong, Mayo, Mark, Holden, M T G, Parkhill, Julian, Mayo, M, Thong, Phe, Kham, C, De Smet, Birgit, Currie, BJ, Peacock, Sharon J, Sarovich, D S   +38 more
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Whole genome sequencing reveals local transmission patterns of mycobacterium bovis in sympatric cattle and badger populations [PDF]

, 2012
Whole genome sequencing (WGS) technology holds great promise as a tool for the forensic epidemiology of bacterial pathogens. It is likely to be particularly useful for studying the transmission dynamics of an observed epidemic involving a largely ...
O'Hare, Anthony, Stanley McDowell, Mallon Tom, Orton, Richard, Mallon, Tom, Biek, R., O'Hare, A., Robin A. Skuce (116935), Kao, R.R., Skuce, Robin A, Tom Mallon, David Wright, Orton Richard J., Kao, Rowland R., Rowland R Kao, McCormick, Carl, Wright David, Biek Roman, Hannah Trewby (116929), Richard J. Orton (116918), Skuce Robin A., Hannah Trewby, McDowell, S., Kao Rowland R., Kao, Rowland R, Trewby, Hannah, Carl McCormick, Skuce, Robin A., Tom Mallon (116914), McCormick, C., David Wright (116911), Mallon, T., Roman Biek (21981), Roman Biek, Wright, D., McCormick Carl, Richard J Orton, McDowell, Stanley, Trewby Hannah, Orton, Richard J., Anthony O'Hare (116908), O'Hare Anthony, McDowell Stanley, Trewby, H., Robin A Skuce, Wright, David; id_orcid, Biek, Roman, Carl McCormick (116915), Stanley McDowell (116923), Wright, David, Orton, R.J., Rowland R. Kao (116940), Skuce, R.A., Anthony O'Hare   +53 more
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Routine use of microbial whole genome sequencing in diagnostic and public health microbiology [PDF]

, 2012
This work is partly supported by funding from the Medical Research Council, the European Developing Country Clinical Trials Partnership, the Global Alliance for TB Drug Development, and the European Union.Whole genome sequencing (WGS) promises to be ...
Holden, MTG, Matthew T G Holden, Mark Farrington (148224), Cartwright, EJP, Matthew T. G. Holden (130258), Brown, Nicholas M., Sharon J Peacock, Bentley, SD, Ellington, Matthew J., Claudio U Köser, Parkhill, J, Stephen D. Bentley (137281), Stephen H Gillespie, Stephen D Bentley, Köser, CU, Bentley, Stephen D., Julian Parkhill (30393), Holden, Matthew T. G., Julian Parkhill, Peacock, Sharon J., Edward J. P. Cartwright (148213), Koeser, Claudio U., Peacock, SJ, Stephen H. Gillespie (148218), Edward J P Cartwright, Gordon Dougan, Matthew J. Ellington (148208), Farrington, M, Cartwright, Edward J. P., Dougan, Gordon, Nicholas M Brown, Parkhill, Julian, Mark Farrington, Gordon Dougan (30395), Farrington, Mark, Claudio U. Köser (148202), Gillespie, Stephen H., Matthew J Ellington, Brown, NM, Sharon J. Peacock (35782), Gillespie, SH, Ellington, MJ, Nicholas M. Brown (148222), Dougan, G   +43 more
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