Results 141 to 150 of about 101,148 (258)

Beyond accuracy: Quantifying the reliability of multiple instance learning for whole slide image classification. [PDF]

PLoS One
Keshvarikhojasteh H, Aubreville M, Bertram CA, Pluim JPW, Veta M.   +4 more
europepmc   +1 more source

Mobile whole slide imaging with Indian twist

Indian Journal of Pathology and Microbiology, 2018
Himanshu Dilip Mulay, Anil K Reddy, Balasaheb R Yelikar   +2 more
openaire   +3 more sources

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Deep learning quantifies pathologists' visual patterns for whole slide image diagnosis. [PDF]

Nat Commun
Nan T, Zheng S, Qiao S, Quan H, Gao X, Niu J, Zheng B, Guo C, Zhang Y, Wang X, Zhao L, Wu Z, Guo Y, Li X, Zou M, Ning S, Zhao Y, Qian W, Chen H, Qi R, Gao X, Cui X.   +21 more
europepmc   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

Corrigendum: Deep Learning for Whole Slide Image Analysis: An Overview

Frontiers in Medicine, 2020
Neofytos Dimitriou, Ognjen Arandjelović, Peter D. Caie   +2 more
doaj   +1 more source

A deep learning and morphometric hybrid model for automated quantification of kidney interstitial fibrosis in trichrome-stained whole-slide image. [PDF]

J Pathol Inform
Athavale A, Patel T, Ix J, Bharati S, Ortuno N, Kulkarni H.   +5 more
europepmc   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

An efficient context-aware approach for whole-slide image classification. [PDF]

iScience, 2023
Shen H, Wu J, Shen X, Hu J, Liu J, Zhang Q, Sun Y, Chen K, Li X.   +8 more
europepmc   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source