Results 71 to 80 of about 196,015 (277)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Reproducibility in the automated quantitative assessment of HER2/neu for breast cancer

Journal of Pathology Informatics, 2013
Background: With the emerging role of digital imaging in pathology and the application of automated image-based algorithms to a number of quantitative tasks, there is a need to examine factors that may affect the reproducibility of results. These factors
Tyler Keay, Catherine Conway, Neil O′Flaherty, Stephen M Hewitt, Katherine Shea, Marios A Gavrielides   +5 more
doaj   +1 more source

Data for glomeruli characterization in histopathological images

Data in Brief, 2020
The data presented in this article is part of the whole slide imaging (WSI) datasets generated in European project AIDPATH 2 This data is also related to the research paper entitle “Glomerulosclerosis Identification in Whole Slide Images using Semantic ...
Gloria Bueno, Lucia Gonzalez-Lopez, Marcial Garcia-Rojo, Arvydas Laurinavicius, Oscar Deniz   +4 more
doaj   +1 more source

User friendly, cloud based, whole slide image segmentation

Medical Imaging 2021: Digital Pathology, 2021
Convolutional neural networks, the state of the art for image segmentation, have been successfully applied to histology images by many computational researchers. However, the translatability of this technology to clinicians and biological researchers is limited due to the complex and undeveloped user interface of the code, as well as the extensive ...
Brendon, Lutnick, Avinash, Kammardi Shashiprakash, David, Manthey, Pinaki, Sarder   +3 more
openaire   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Implementation of whole slide imaging in surgical pathology: A value added approach

Journal of Pathology Informatics, 2011
Background: Whole slide imaging (WSI) makes it possible to capture images of an entire histological slide. WSI has established roles in surgical pathology, including support of off-site frozen section interpretation, primary diagnosis, educational ...
Mike Isaacs, Jochen K Lennerz, Stacey Yates, Walter Clermont, Joan Rossi, John D Pfeifer   +5 more
doaj   +1 more source

Developing the Quantitative Histopathology Image Ontology : A case study using the hot spot detection problem [PDF]

, 2017
Interoperability across data sets is a key challenge for quantitative histopathological imaging. There is a need for an ontology that can support effective merging of pathological image data with associated clinical and demographic data.
Doyle, Scott, Gurcan, Metin, James, A., John, Overton, N., Tomaszewski, Ruttenberg, Alan, Smith, Barry   +6 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Validation of a whole slide imaging system for primary diagnosis in surgical pathology: A community hospital experience

Journal of Pathology Informatics, 2014
Guidelines for validating whole slide imaging (WSI) for primary diagnosis in surgical pathology have been recommended by an expert panel commissioned by the College of American Pathologists.
Thomas P Buck, Rebecca Dilorio, Lauren Havrilla, Dennis G O′Neill   +3 more
doaj   +1 more source

A Compact Representation of Histopathology Images using Digital Stain Separation & Frequency-Based Encoded Local Projections

, 2019
In recent years, histopathology images have been increasingly used as a diagnostic tool in the medical field. The process of accurately diagnosing a biopsy sample requires significant expertise in the field, and as such can be time-consuming and is prone
AC Ruifrok, Andrew Janowczyk, DG Lowe, F Mendivil, HR Tizhoosh, MN Gurcan, T Ahonen, U Molter   +7 more
core   +1 more source