Results 71 to 80 of about 197,897 (274)

Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis Model [PDF]

, 2013
poster abstractDigital whole slide imaging is the technique of digitizing a microscope slide at the highest resolution to produce a “digital virtual microscope slide”.
Peterson, Kacie M., Pollok, Karen E., Sandusky, George E., Silver, Jayne M., Sinn, Anthony L., Surface, Ronne Leigh, Tonsing-Carter, Eva   +6 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Deep-Learning for Classification of Colorectal Polyps on Whole-Slide Images

, 2017
Histopathological characterization of colorectal polyps is an important principle for determining the risk of colorectal cancer and future rates of surveillance for patients. This characterization is time-intensive, requires years of specialized training,
Hassanpour, Saeed, Korbar, Bruno, Miraflor, Allen P., Nicka, Katherine M., Olofson, Andrea M., Suriawinata, Arief A., Suriawinata, Matthew A., Torresani, Lorenzo   +7 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Tumor proliferation assessment of whole slide images [PDF]

Medical Imaging 2018: Digital Pathology, 2018
Grading whole slide images (WSIs) from patient tissue samples is an important task in digital pathology, particularly for diagnosis and treatment planning. However, this visual inspection task, performed by pathologists, is inherently subjective and has limited reproducibility. Moreover, grading of WSIs is time consuming and expensive.
Rousson M., Hedlund M., Andersson M., Jacobsson L., Lathen G., Norell B., Jimenez-Del-Toro O., Mueller H., Atzori M.   +8 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

RT-4M: Real-Time Mosaicing Manager for Manual Microscopy System

Sensors
The creation of virtual slides, i.e., high-resolution digital images of biological samples, is expensive, and existing manual methods often suffer from stitching errors and additional reimaging costs.
Nobuhito Mori, Yoshihiro Miyazaki, Tatsuya Oda, Yasuyuki S. Kida   +3 more
doaj   +1 more source

Virtual microscopy in the undergraduate teaching of pathology

Journal of Pathology Informatics, 2015
Background: Little evidence is available concerning the impact of virtual microscopy (VM) in the undergraduate teaching of pathology. We aimed: (1) to determine the impact in student scores when moving from conventional microscopy (CM) to VM; (2) to ...
Oriol Ordi, Josep Antoni Bombí, Antonio Martínez, Josep Ramírez, Llúcia Alòs, Adela Saco, Teresa Ribalta, Pedro L Fernández, Elias Campo, Jaume Ordi   +9 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Interactive case vignettes utilizing simulated pathologist-clinician encounters with whole slide imaging and video tutorials of whole slide scans improves student understanding of disease processes

Journal of Pathology Informatics, 2012
Background: One of the drawbacks of studying pathology in the second year of medical school in a classroom setting is the relatively limited exposure to patient encounters/clinical rotations, making it difficult to understand and fully appreciate the ...
Adam J Horn, Donna Czarnecki, Subodh M Lele   +2 more
doaj   +1 more source