A case of left atrial myxoma accompanied by pancytopenia and pathological findings suggestive of pulmonary hypertension [PDF]
A case of left atrial myxoma accompanied by peculiar symptoms is reported. A 15-year old boy had progressive congestive heart failure and three episodes of acute attacks of panctyopenia. The anemia was accompanied by helmet-shaped, broken red blood cells,
Kawanishi, Koichi +3 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Temu putih (Curcuma zedoria Rosc.) contains essential oils that have antibacterial effects, in which one of the example is against Salmonella typhi. The aim of this study is to find out the anti-typhoid effect of essential oil from temu putih in rat ...
Aprilita Rina Yanti Eff
doaj
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
APPLICATION OF NEURAL NETWORKS ON BLOOD SERUM IMAGE FOR EARLY DETECTION OF TYPHUS
Background: Typhus is a disease caused by Salmonella typhi, Salmonella paratyphi A Salmonella parathypi B, dan Salmonella paratyphi C bacteria that attacks digestive tract and caused infection in small intestine.
Betty Purnamasari +2 more
doaj +1 more source
A genome-wide case-only test for the detection of digenic inheritance in human exomes [PDF]
Gaspard Kerner +8 more
openalex +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Genome-wide multimediator analyses using the generalized Berk–Jones statistics with the composite test [PDF]
En‐Yu Lai, Yen‐Tsung Huang
openalex +1 more source
One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke [PDF]
BACKGROUND Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke.
Albers, Gregory W. +20 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source

