Results 91 to 100 of about 2,155,111 (338)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gyrotorque transmission system for wind turbines [PDF]

, 2004
The GyroTorqueTM transmission system employs gyroscopic torque reaction to transmit power offering an alternative to the gearbox and electrical variable speed drive of a conventional wind turbine.
Jamieson, P., Jegatheeson, M., Leithead, W.E.   +2 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

An analysis of a QND speed-meter interferometer

, 2004
In the quest to develop viable designs for third-generation optical interferometric gravitational-wave detectors (e.g. LIGO-III and EURO), one strategy is to monitor the relative momentum or speed of the test-mass mirrors, rather than monitoring their ...
A. Abramovici, A. Buonanno, A. Buonanno, A. Buonanno, B. Caron, B.C. Barish, B.L. Schumaker, C.M. Caves, C.M. Caves, C.M. Caves, C.M. Caves, F.Ya. Khalili, H. Lück, H.J. Kimble, K. Kuroda, M.T. Jaekel, Patricia Purdue, S.P. Vyatchanin, S.P. Vyatchanin, S.P. Vyatchanin, S.P. Vyatchanin, S.P. Vyatchanin, S.P. Vyatchanin, S.P. Vyatchanin, V.B. Braginsky, V.B. Braginsky, V.B. Braginsky, V.B. Braginsky, V.B. Braginsky, V.B. Braginsky, V.B. Braginsky   +30 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Investigation of a Tube-Launched Unmanned Aerial Vehicle with a Variable-Sweep Wing

Drones
Foldable wings are designed for tube-launched unmanned aerial vehicles (UAVs), aiming to improve portability and meet launch platform requirements. However, conventional tube-launched UAVs cannot operate across the wide speed ranges required for the ...
Peng Si, Mingjian Wu, Yongqing Huo, Zhilin Wu   +3 more
doaj   +1 more source

Scramjet nozzle design and analysis as applied to a highly integrated hypersonic research airplane [PDF]

Engine-nozzle airframe integration at hypersonic speeds was conducted by using a high-speed research aircraft concept as a focus. Recently developed techniques for analysis of scramjet-nozzle exhaust flows provide a realistic analysis of complex forces ...
Johnston, P. J., Small, W. J., Weidner, J. P.   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source