Results 81 to 90 of about 1,824,485 (310)

Road-killed wild animals: a preservation problem useful for eco-epidemiological studies of pathogens [PDF]

, 2010
Road-killed wild animals have been for years used for surveillance of vectors of zoonotic pathogens and may offer new opportunities for eco-epidemiological studies.
BAGAGLI, E, BARROZO, L, BOSCO, SMG, RICHINI-PEREIRA, VB, THEODORO, RC   +4 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mycobacterium avium Complex in domestic and wild animals [PDF]

, 2013
Mycobacteria from the Mycobacterium avium complex (MAC) cause a variety of diseases including tuberculosis-like disease in humans and birds, disseminated infections in AIDS patients and otherwise immunocompromised patients, lymphadenitis in humans and ...
Coelho, A.C., Matos, A.C., Matos, M., Pinto, M.L., Pires, M.A.   +4 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
A. Abdelrahman, A. F. Pfeiffer, AR Josse, AW Barclay, B. Thorens, C Yamada, C Zhang, Coon PJ, Rogus EM, Drinkwater D, Muller DC, Goldberg AP, DB Pawlak, DB Pawlak, DS Ludwig, DW Foster, EM Schothorst van, EO Diaz, F Isken, F Isken, F Preitner, F. Isken, J Brand-Miller, J Salmeron, J Salmeron, J Stevens, JA Marshall, JJ Holst, JJ Meier, K Miyawaki, KA Meyer, KB Scribner, KB Scribner, KH Ding, M Kabir, M Lerer-Metzger, M. H. Tschöp, M. Möhlig, M. O. Weickert, MB Schulze, MK Hellerstein, MO Weickert, R. Nogueiras, RM Dam van, S Liu, S. Klaus, SE Byrnes, SJ Gatenby, WM Kohrt, X Pi-Sunyer   +45 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Case Report: Clinical and pathological features of a metastasizing malignant mixed epithelial and stromal tumor of the kidney in a Siberian tiger (Panthera tigris altaica)

Frontiers in Veterinary Science
We describe a case of mixed epithelial and stromal tumor (MEST) of the kidney with widespread metastases in an eight-year-old male Siberian tiger (Panthera tigris altaica) from the ZOO Ljubljana. The tiger presented with hematuria, and after unsuccessful
Tanja Švara, Mitja Gombač, Nika Kojc, Mojca Harej, Marjan Kastelic, Peter Kržan, Tamara Dolenšek, Pavel Kvapil   +7 more
doaj   +1 more source

Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]

, 2018
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J., Guerra, B., Rodicio Rodicio, María del Rosario   +2 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Expanding Global Justice: The International Protection of Animals [PDF]

, 2013
This article examines and rejects the view that nonhuman animals cannot be recipients of justice, and argues that the main reasons in favor of universal human rights and global justice also apply in the case of the international protection of the ...
Horta, Oscar
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