Results 31 to 40 of about 325,483 (256)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Changthangi Pashmina Goat Genome: Sequencing, Assembly, and Annotation
Frontiers in Genetics, 2021 Pashmina goats produce the world's finest and the most costly animal fiber (Pashmina) with an average fineness of 11–13 microns and have more evolved mechanisms than any known goat breed around the globe. Despite the repute of Pashmina goat for producing
Basharat Bhat +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Rug the preserver of wild goat figure since the ancient times [PDF]
نگره, 2012 The importance of animal figure is dramatic in Iranian art since ancient time. Animal figures were sometimes used as symbols of agriculture and nutrition and also as symbols of gods, kingdoms and elements of universe.
Effatolsadat Afzaltousi
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
HELMINTH FAUNA IN FARM AND WILD RUMINANTS ON THE PASTURES OF CHECHEN REPUBLIC
Российский паразитологический журнал, 2016 Helminth fauna of farm and wild ruminants grazed on common pastures, in mountain areas of distribution of wild animal (tur, roe deer, Persian wild goat, gemsa) and in south regions (roe deer) was studied.
H. H. Gadaev
doaj
Journal of Zoonotic DiseasesWild and domestic ruminants become infected with Mycobacterium avium subsp. paratuberculosis (MAP) leads to chronic enteritis, known as Johne’s disease (JD).
Mohammadreza Ghorani +4 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Courtship behaviour of the wild goat
, 1973 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Schaller, George B., Laurie, Andrew
openaire +2 more sources