Results 41 to 50 of about 324,956 (256)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The First Report of Rhipicephalus (Boophilus) kohlsi (Hoog¬straal and Kaiser 1960) from Wild Goats (Capra hircus aega¬grus) in Iran [PDF]

Iranian Journal of Parasitology, 2007
Background: Studies concerning ticks were of interest to evaluate the distribution and composition of species affecting live¬stock, thus it was a main step in our knowledge of the pathogens that they may transmit by tick.
S Rahbari, S Nabian   +1 more
doaj   +1 more source

Characterization of 12S rRNA gene for meat identification of common wild and domestic small herbivores as an aid to wildlife forensic

Veterinary World, 2013
Aim: Chital and sambar are the common wild small herbivores, which are vulnerable to poaching for their meat. Many times poachers claim the wild meat to be that of goat or sheep. Hence, authentic evidences are required to stop such wildlife crime.
E. Joseph, Sanjeev Singh, Rakesh Ranjan, S.N.S. Parmar, Nidhi Rajput, A.B. Shrivastav   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Habitat suitability modeling for wild goat (Capra aegagrus) in a mountainous arid area, central Iran

Caspian Journal of Environmental Sciences, 2013
Wild goat (Capra aegagrus) is one of the most prominent mountain mammals dispersed in many habitats in Iran. However, few studies on the relationship between this species and its habitat have been conducted.
Sarhangzadeh, J., Yavari, A.R., Hemami, M.R., Jafari, H.R., Shams-Esfandabad, B.   +4 more
doaj  

Genetic origin of goat populations in Oman revealed by mitochondrial DNA analysis.

PLoS ONE, 2017
The Sultanate of Oman has a complex mosaic of livestock species and production systems, but the genetic diversity, demographic history or origins of these Omani animals has not been expensively studied. Goats might constitute one of the most abundant and
Nasser Ali Al-Araimi, Osman Mahgoub Gaafar, Vânia Costa, Agusto Luzuriaga Neira, Raed Mahmoud Al-Atiyat, Albano Beja-Pereira   +5 more
doaj   +1 more source

Relationship Between in situ Conserved Wild Wheat Species, Associated Plants and Soil Characteristics

Journal of Agricultural Sciences, 2009
A comprehensive knowledge of the ecology and associating plant species of wheat progenitors is important for plant scientists. This study was designed as a case study to focus on the relation between 5 wild relatives of wheat Aegilops spp. L.
Alptekin Karagöz, Çetin Arcak, İbrahim Hakkı Güçdemir   +2 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source