Results 41 to 50 of about 75,765 (265)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Chromosome-level genome assembly of the tetraploid medicinal and natural dye plant Persicaria tinctoria

Scientific Data
Persicaria tinctoria (2n = 40) is an important traditional medicinal plant and natural dye source within the genus Persicaria. P. tinctoria has been utilized for its antibacterial, antiviral, anti-inflammatory, and tumor treatment properties ...
Qing Li, Hui Huang, Ruyan Fan, Qiannan Ye, Yanting Hu, Zhenzhen Wu, Chengjun Zhang, Yuhua Wang   +7 more
doaj   +1 more source

Effects of mode of reproduction on genetic polymorphism and divergence in wild yams (Dioscoreaceae: Dioscorea)

Plant Diversity
Evolutionary transitions from sexual to asexual reproduction should have significant influences on genetic divergence and polymorphism at the genome level.
Xin Wang, Qing-Hong Feng, Zhi-Hua Zeng, Zhi-Qiang Zhang, Jie Cai, Gao Chen, De-Zhu Li, Hong Wang, Wei Zhou   +8 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Human agricultural activities influence the flowering time of turnip in the Qinghai-Tibet Plateau

Plant Diversity
Tibetan turnip and oilseeds are the most important vegetables cultivated in the Qinghai-Tibet Plateau. Our field observations identified a dominant early-bolting phenotype at the vegetative growth stage in the Tibetan turnip, which was possibly due to ...
Yan Zheng, Landi Luo, Xieshengyang Li, Qian Chen, Ya Yang, Yuanwen Duan, Xiangxiang Kong, Yongping Yang   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Dynamic transcriptomic features accompanying the onset of first flowering in roses

BMC Plant Biology
Background Onset time of the first flowering is pivotal for the reproductive success of perennial polycarpic plants especially in woody species, like roses.
Jing Wen, Jiu-Xia Zhao, Mi-Cai Zhong, Wei-Hua Cui, Shi-Zhao Zhou, Dan Wang, Shu Wang, Chun-Tao Wang, Xiao-Dong Jiang, Jin-Yong Hu   +9 more
doaj   +1 more source

Combatting environmental impacts and microbiological pollution risks in Potato cropping: Benefits of forage cultivation in a semi-arid region

Resources, Environment and Sustainability
Continuous potato cropping in semi-arid regions, which are vulnerable to erosion, reduces tuber yields and leads to a decline in soil quality. This research delves into the impact of forage cultivation on soil bacterial and archaeal communities and the ...
Xudong Sun, Yousif Abdelrahman Yousif Abdellah, Guangyan Wang, Huasen Wang, Jishao Jiang, Yu Zhang, Caspar C.C. Chater, Yongping Yang, Yuanwen Duan, Fuqiang Yu, Dong Liu   +10 more
doaj   +1 more source