Results 71 to 80 of about 75,765 (265)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Comparative and phylogenetic analyses of the chloroplast genomes of mangrove plants

Scientific Reports
Mangrove ecosystems play a crucial role in coastal environment by stabilizing shorelines, reducing erosion, and providing habitat for diverse wildlife. However, there are fewer studies on the genetic management of mangrove plants.
Jigui Yuan, Wei Gu, Haijie Yang, Mei Wang   +3 more
doaj   +1 more source

Ecological assessment of Iris hookeriana across subalpine and alpine regions of the Hindu-Himalayas

Frontiers in Forests and Global Change
IntroductionThe Hindu-Himalayan region, a global biodiversity, hotspot harbors numerus endemic plant species that contribute significantly to ecosystem stability.
Muhammad Shakeel Khan, Shujaul Mulk Khan, Abdullah, Abdullah, Jie Liu, Jie Liu, Zeng-Yuan Wu, Zeng-Yuan Wu, Jawad Hussain, Shakil Ahmad Zeb, Nazir Mohammad, Zareena Batool, Zafeer Saqib, Rabia Afza, Fazal Manan, Shahab Ali   +15 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Checklist and prioritization of crop wild relatives in Sudan and South Sudan

Genetic Resources
Crop wild relatives (CWR) encompass wild plant species or subspecies closely related to domesticated crops. This study presents the first comprehensive checklist and prioritized inventory of CWR for Sudan and South Sudan.
Ahmed Aldow, Joana Magos Brehm, Maha Kordofani, Fatouma Abdoul-latif, Nigel Maxted   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Identification of herbal medicine species of Lysimachia L. (Primulaceae) in Southern China using genome skimming

BMC Plant Biology
Background The accurate identification of herbal medicine is a prerequisite for safe and effective use. DNA barcoding has been widely used for the identification of herbal medicine.
Li-Na Dong, Zhi-Fang Liu, Wei-Bin Xu, Jun-Bo Yang, Catherine A. Kidner, Mark Hughes, Hai-Fei Yan, Hong Wang, De-Zhu Li   +8 more
doaj   +1 more source

Population genetic insights into the conservation of common walnut (Juglans regia) in Central Asia

Plant Diversity
The common walnut (Juglans regia) is one of the most economically important nut trees cultivated worldwide. Despite its importance, no comprehensive evaluation of walnut tree population genetics has been undertaken across the range where it originated ...
Linjiang Ye, Robabeh Shahi Shavvon, Hailing Qi, Hongyu Wu, Pengzhen Fan, Mohammad Nasir Shalizi, Safiullah Khurram, Mamadzhanov Davletbek, Yerlan Turuspekov, Jie Liu   +9 more
doaj   +1 more source