Results 91 to 100 of about 1,079,692 (209)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Multifaceted plant diversity patterns across the Himalaya: Status and outlook

Plant Diversity
Mountains serve as exceptional natural laboratories for studying biodiversity due to their heterogeneous landforms and climatic zones. The Himalaya, a global biodiversity hotspot, hosts rich endemic flora, supports vital ecosystem functions, and offers a
Mustaqeem Ahmad, Ya-Huang Luo, Sonia Rathee, Robert A. Spicer, Jian Zhang, Moses C. Wambulwa, Guang-Fu Zhu, Marc W. Cadotte, Zeng-Yuan Wu, Shujaul Mulk Khan, Debabrata Maity, De-Zhu Li, Jie Liu   +12 more
doaj   +1 more source

Crop wild relatives in Vologda Province

Труды по прикладной ботанике, генетике и селекции, 2019
Background. Searching for new sources of genes for cultivated plants in order to increase their productivity, earliness, resistance, etc. is the vital problem of scientific work, since the need of mankind for food has increased in recent years many times.
L. Yu. Shipilina
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Identification and characterization of nine PAT1 genes subfamily in Medicago edgeworthii

Plant Signaling & Behavior
GRAS proteins represent a unique class of transcription factors that are exclusive to plants. Among the various subfamilies within the GRAS family, the phytochrome A signal transduction 1 (PAT1) subfamily is particularly prominent, given its multifaceted
Gaoping Tang, Tingting Ni, García-Caparrós Pedro, Li-Hua Meng, Xudong Sun   +4 more
doaj   +1 more source

Using crop wild relatives as sources of useful genes

, 2005
Wild plant genetic resources (PGR), and particularly crop wild relatives, represent a source of useful germplasm for the present and future generations. In the past, the majority of the information on PGR was based on phenotype, geographic origin, social
Sonnante G, Pignone D
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluating the utility of deep genome skimming for phylogenomic analyses: A case study in the species-rich genus Rhododendron

Plant Diversity
Deep genome skimming (DGS) has emerged as a promising approach to recover orthologous nuclear genes for large-scale phylogenomic analyses. However, its reliability with low DNA quality and quantity typical of archival specimens, such as herbarium ...
Zhi-Qiong Mo, Chao-Nan Fu, Alex D. Twyford, Pete M. Hollingsworth, Ting Zhang, Jun-Bo Yang, De-Zhu Li, Lian-Ming Gao   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya

Global Ecology and Conservation
Global climate change threatens the spatiotemporal distribution and resilience of species, especially those in mountainous regions. The Himalaya, a global biodiversity hotspot, harbors one of the richest medicinal plant communities, which are ...
Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu   +7 more
doaj   +1 more source