Results 71 to 80 of about 76,572 (264)

The Mating System of the Wild-to-Domesticated Complex of Gossypium hirsutum L. Is Mixed

Frontiers in Plant Science, 2018
The domestication syndrome of many plants includes changes in their mating systems. The evolution of the latter is shaped by ecological and genetic factors that are particular to an area.
Rebeca Velázquez-López, Ana Wegier, Valeria Alavez, Javier Pérez-López, Valeria Vázquez-Barrios, Denise Arroyo-Lambaer, Alejandro Ponce-Mendoza, William E. Kunin   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multifaceted plant diversity patterns across the Himalaya: Status and outlook

Plant Diversity
Mountains serve as exceptional natural laboratories for studying biodiversity due to their heterogeneous landforms and climatic zones. The Himalaya, a global biodiversity hotspot, hosts rich endemic flora, supports vital ecosystem functions, and offers a
Mustaqeem Ahmad, Ya-Huang Luo, Sonia Rathee, Robert A. Spicer, Jian Zhang, Moses C. Wambulwa, Guang-Fu Zhu, Marc W. Cadotte, Zeng-Yuan Wu, Shujaul Mulk Khan, Debabrata Maity, De-Zhu Li, Jie Liu   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Identification and characterization of nine PAT1 genes subfamily in Medicago edgeworthii

Plant Signaling & Behavior
GRAS proteins represent a unique class of transcription factors that are exclusive to plants. Among the various subfamilies within the GRAS family, the phytochrome A signal transduction 1 (PAT1) subfamily is particularly prominent, given its multifaceted
Gaoping Tang, Tingting Ni, García-Caparrós Pedro, Li-Hua Meng, Xudong Sun   +4 more
doaj   +1 more source

Climate change impacts on Rhododendron diversity: Regional responses and conservation strategies in China

Plant Diversity
Over the past century, anthropogenic greenhouse gas emissions have continuously increased global temperature and triggered climate change, significantly impacting species distributions and biodiversity patterns. Understanding how climate-driven shifts in
Ming-Shu Zhu, Zhi-Qiong Mo, Michael Möller, Ting Zhang, Chao-Nan Fu, Jie Cai, Wei Zheng, Ya-Huang Luo, De-Zhu Li, Lian-Ming Gao   +9 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Evaluating the utility of deep genome skimming for phylogenomic analyses: A case study in the species-rich genus Rhododendron

Plant Diversity
Deep genome skimming (DGS) has emerged as a promising approach to recover orthologous nuclear genes for large-scale phylogenomic analyses. However, its reliability with low DNA quality and quantity typical of archival specimens, such as herbarium ...
Zhi-Qiong Mo, Chao-Nan Fu, Alex D. Twyford, Pete M. Hollingsworth, Ting Zhang, Jun-Bo Yang, De-Zhu Li, Lian-Ming Gao   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source