Results 111 to 120 of about 1,079,692 (209)

Identification of herbal medicine species of Lysimachia L. (Primulaceae) in Southern China using genome skimming

BMC Plant Biology
Background The accurate identification of herbal medicine is a prerequisite for safe and effective use. DNA barcoding has been widely used for the identification of herbal medicine.
Li-Na Dong, Zhi-Fang Liu, Wei-Bin Xu, Jun-Bo Yang, Catherine A. Kidner, Mark Hughes, Hai-Fei Yan, Hong Wang, De-Zhu Li   +8 more
doaj   +1 more source

Crop Wild Relatives (CWRs) in the United Arab Emirates: Resources for Climate Resilience and Their Potential Medicinal Applications [PDF]

Ramya Manoharan,1 Chythra Somanathan Nair,1 Drishya Nishanth,1 Radhakrishnan Subramanian,1 Xiulan Xie,2 Maozhi Ren,2 Abdul Jaleel1 1Department of Integrative Agriculture, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al
Xie X, Jaleel A, Manoharan R, Ren M, Nair CS, Subramanian R, Nishanth D   +6 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cascaded regulatory network composed of small RNAs involves in the symbiosis of Panax notoginseng and fungus Acremonium sp. D212

Scientific Reports
Panax notoginseng (P. notoginseng) is a valuable traditional Chinese medical herb with multiple pharmacological effects, and Acremonium sp. D212 is a symbiotic fungus.
Baolin Yao, Haiyan Zhu, Xie He, Wenjing Yang, Chongyu Luo, Yan Li, Ao Yang, Yinhui Zhang, Lihui Jiang, Yaqiong Li, Liwei Guo, Xiahong He, Yunlong Du, Changning Liu   +13 more
doaj   +1 more source

Population genetic insights into the conservation of common walnut (Juglans regia) in Central Asia

Plant Diversity
The common walnut (Juglans regia) is one of the most economically important nut trees cultivated worldwide. Despite its importance, no comprehensive evaluation of walnut tree population genetics has been undertaken across the range where it originated ...
Linjiang Ye, Robabeh Shahi Shavvon, Hailing Qi, Hongyu Wu, Pengzhen Fan, Mohammad Nasir Shalizi, Safiullah Khurram, Mamadzhanov Davletbek, Yerlan Turuspekov, Jie Liu   +9 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

SSR_VibraProfiler: a Python package for accurate classification of varieties using SSRs with intra-variety specificity and inter-variety polymorphism

Plant Methods
Background Simple sequence repeats (SSRs) are widely used as molecular markers; however, traditional development of SSR molecular markers heavily relies on experimental methods. The advancement of modern sequencing technology has provided the possibility
Chenhao Jiang, Chuan Dong, Zhenzhen Wu, Chenyi Shi, Qiannan Ye, Xiaopei Wu, Siyi Ma, Yuming Wen, Guoping Yu, Jiasheng Wu, Chengjun Zhang   +10 more
doaj   +1 more source

Monitoring and Evaluation Plan Multiplication of Crop Wild Relatives (CWR)

, 2021
The document provides an overview of the monitoring and evaluation (M&E) plan for the project “Multiplication of Crop Wild Relatives” implemented by the genebank of ICARDA in Lebanon.
Jeitani, Asma
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source