Results 51 to 60 of about 262,063 (287)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Unveiling Sri Lanka’s Wilderness: GIS-Based Modelling of Wilderness Attributes

Land
This research presents the first detailed national wilderness mapping project conducted in Sri Lanka, aiming to identify and assess the spatial distribution of wilderness areas in the country. The study utilises a GIS-based Wilderness Quality Index (WQI),
Uthpala Mudalige, Steve Carver
doaj   +1 more source

Witnessing the Wilderness [PDF]

, 2012
The exhibition interrogates our preconceptions of the wilderness,and the role of the artist as adventurer, witness and mediator. Wilderness is both physical topography and a social and cultural construct, promising an untrammelled refuge or a stage for ...
Evans, Geraint
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Different people, different wild: Comparing and mapping wilderness representation in Wuyishan National Park, China

Geography and Sustainability
It is essential to better integrate wilderness representations of different stakeholders into wilderness conservation. The way in which local residents and other stakeholders frame the construction of wilderness of protected areas in developing countries
Aifang Weng, Lingyun Liao, Yue Cao, Steve Carver, Li Lin, Siyuan Shen, Zhengduo Xu, Jianwen Dong, Siren Lan, Rui Yang   +9 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Research on wilderness area identification and distribution of spatial characteristics based on Boolean-multi-indicator evaluation approach —a case study of wilderness areas in Henan Province, China

Frontiers in Environmental Science
Under the background of global anthropocene and climate change, as a key spatial unit to maintain the function of native ecosystems, the study of precise identification and spatial distribution of wilderness is of great scientific value to enhance the ...
Yaping Ren, Shuyi Wang, Bifeng Cui, Yu Ding, Runxiang Cao   +4 more
doaj   +1 more source

Measuring MPAs in Continental North America: How Well Protected Are the Ocean Estates of Canada, Mexico, and the USA?

Frontiers in Marine Science, 2017
Marine protected areas (MPAs) are a well-established conservation strategy, employed around the world to protect important marine species and ecosystems and support the recovery of declining populations.
Sabine Jessen, Lance E. Morgan, Juan E. Bezaury-Creel, Alexandra Barron, Rhona Govender, Elizabeth P. Pike, Vienna R. Saccomanno, Russell A. Moffitt   +7 more
doaj   +1 more source

Lee Chapel: Lost Cause Artifact and Culture Shock [PDF]

, 2011
I had the privilege to accompany a group of undergraduate students recently on a whirlwind tour of the Wilderness, Richmond and Appomattox. Our tour took us along the I-81 corridor on the way back to Gettysburg, so why not stop in Lexington for a Civil ...
Rudy, John M.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source