Results 51 to 60 of about 34,166 (314)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Wilderness

, 2017
What we perceive to be wilderness is in fact just a product: a physical manifestation of the force of wildness. Attempting to manufacture wilderness while bypassing this primary element (the force of wilderness) is why ‘emulated wilds’ often feel uncanny,
Prujean, Alexander (11741720), Prujean, Alexander   +1 more
core   +1 more source

Unveiling Sri Lanka’s Wilderness: GIS-Based Modelling of Wilderness Attributes

Land
This research presents the first detailed national wilderness mapping project conducted in Sri Lanka, aiming to identify and assess the spatial distribution of wilderness areas in the country. The study utilises a GIS-based Wilderness Quality Index (WQI),
Uthpala Mudalige, Steve Carver
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Different people, different wild: Comparing and mapping wilderness representation in Wuyishan National Park, China

Geography and Sustainability
It is essential to better integrate wilderness representations of different stakeholders into wilderness conservation. The way in which local residents and other stakeholders frame the construction of wilderness of protected areas in developing countries
Aifang Weng, Lingyun Liao, Yue Cao, Steve Carver, Li Lin, Siyuan Shen, Zhengduo Xu, Jianwen Dong, Siren Lan, Rui Yang   +9 more
doaj   +1 more source

Wilderness Communications [PDF]

Wilderness & Environmental Medicine, 2011
When an emergency situation arises in a remote location, the ability to communicate with outside sources of assistance can prove very valuable. This article reviews the different types of communications technologies available to individuals in remote locations, including satellite telephones, personal locator beacons, satellite messengers, cellular ...
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Research on wilderness area identification and distribution of spatial characteristics based on Boolean-multi-indicator evaluation approach —a case study of wilderness areas in Henan Province, China

Frontiers in Environmental Science
Under the background of global anthropocene and climate change, as a key spatial unit to maintain the function of native ecosystems, the study of precise identification and spatial distribution of wilderness is of great scientific value to enhance the ...
Yaping Ren, Shuyi Wang, Bifeng Cui, Yu Ding, Runxiang Cao   +4 more
doaj   +1 more source