Results 101 to 110 of about 2,262,131 (334)

Using Technology to Enhance Rural Resilience in Pre-hospital Emergencies [PDF]

, 2015
The research presented in this paper is supported by RCUK dot.rural Digital Economy Research Hub, University of Aberdeen [grant number EP/G066051/1].Peer reviewedPublisher ...
Kindness, Peter, Mellish, Chris, Mort, Alasdair, Reiter, Ehud, Schneider, Anne Helen, Wilson, Philip   +5 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Novel drugs in the management of acute mountain sickness and high altitude pulmonary edema

Open Access Journal of Sports Medicine, 2015
Gaurav Sikri, Anirban Bhattacharya Department of Physiology, Armed Forces Medical College, Wanowarie, Pune, IndiaWe read with great interest the review article titled “Wilderness medicine at high altitude: recent developments in the field” by
Sikri G, Bhattacharya A
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Wilderness Medicine Physician Education: How an Elective Can Spark a Fire. [PDF]

Cureus, 2021
Belyea A, Fish A, Phillips L.
europepmc   +1 more source

Wilderness Medicine [PDF]

Academic Emergency Medicine, 1994
B A, Zlotnick, M R, Monsen, P S, Auerbach   +2 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Wilderness Medicine Education in the Time of Social Distancing and COVID-19. [PDF]

AEM Educ Train, 2021
Hill AD, Pasik SD.
europepmc   +1 more source

Wilderness on the Page [PDF]

, 2017
This essay explores the role that literature can play in a rethinking of Western culture\u27s relationship with the natural ...
Steffler, John
core   +1 more source

Gothic Matters: Introduction [PDF]

, 2016
Once considered escapist or closely linked to fantasy, the Gothic genre (or mode, as scholars increasingly call it) has recently begun to be explored for its material concerns and engagement with real-world matters.
Monnet, Agnieszka Soltysik
core   +2 more sources