Results 31 to 40 of about 49,322 (169)

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Potential risk zone for anthropogenic mortality of carnivores in Gandaki Province, Nepal

Ecology and Evolution, 2022
Anthropogenic pressures in human‐dominated landscapes often contribute to wildlife mortality. Carnivores are especially vulnerable to human‐induced mortality due to the perceived threat to livestock and humans.
Binaya Adhikari, Kedar Baral, Shivish Bhandari, Michelle Szydlowski, Ripu M. Kunwar, Saroj Panthi, Bijaya Neupane, Raj Kumar Koirala   +7 more
doaj   +1 more source

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

A Hybrid Approach for Geo-Referencing Tweets: Transformer Language Model Regression and Gazetteer Disambiguation

ISPRS International Journal of Geo-Information
Recent approaches to geo-referencing X posts have focused on the use of language modelling techniques that learn geographic region-specific language and use this to infer geographic coordinates from text.
Thomas Edwards, Padraig Corcoran, Christopher B. Jones   +2 more
doaj   +1 more source

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Advanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels, Tristan Dedrie, Synnøve K. Mo, Simon Van de Vyver, Thijs R. A. Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled, Alexandra Burnett, Grégory Abrams, Maarten Dhaenens   +12 more
wiley   +1 more source

Rickettsia parkeri Strain Atlantic  Rainforest in Archived Amblyomma geayi from Three-Toed Sloth (Bradypus tridactylus) in Manaus, Brazil

Animals
In the Brazilian Amazon biome, there has been a rise in human spotted fever cases, but still significant knowledge gaps regarding the diversity and epidemiology of the tick–host–Rickettsia relationship.
Rafaela Moreira, Guilherme Moreira, Mahima Hemnani, Carlos Augusto Rodrigues do Nascimento, Sergio Luís Gianizella, João Rodrigo Mesquita, Patrícia Ferreira Barradas   +6 more
doaj   +1 more source

Farmers' Preferences for Gene Editing Crops and Influencing Factors

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Gene editing (GE) is gaining momentum worldwide, but limited data on UK farmers' preferences hinders our understanding of its potential impact amid deregulation debates. Based on a survey of 200 English arable farmers, we employ a Latent Class Analysis and Multinomial Logit regressions to investigate current preferences for GE crops.
Bertolozzi‐Caredio Daniele, Vigani Mauro   +1 more
wiley   +1 more source

Traumatic Oral Lesions in Loggerhead Sea Turtles (Caretta caretta) Linked to Polychaete (Laetmonice cf. hystrix) Ingestion: A Case Report from the Northern Adriatic Sea

Animals
Oral cavity lesions in sea turtles, particularly Caretta caretta, are relatively rare, and are typically linked to infectious agents as well as anthropogenic factors, including ingestion of marine debris or fishing gear.
Stefano Pesaro, Lucia Biagini, Danilo De Bellis, Luca Dorigo, Alice Baggio, Isabella Perlin, Giacomo Rossi   +6 more
doaj   +1 more source

An innovative temporary escape ramp for deer and other wildlife

California Fish and Wildlife Journal, 2021
Concrete-lined water conveyance canals can be a significant source of mortality for ungulates and other wildlife, which can drown or become entrapped. Various types of wildlife escape structures have been deployed in canals with limited success.
Gina E. Morimoto, Anae B. Otto, Laura L. Burkholder   +2 more
doaj   +1 more source

Regional Differences in U.S. Consumer Preferences for Native Woody Shrubs With Varying Aesthetic Characteristics

Agribusiness, EarlyView.
ABSTRACT Native plants offer a variety of aesthetic (e.g., fall colour, fruit, flowers) and functional benefits (e.g., pollinator friendly, wildlife friendly, water management). How these benefits influence consumer choice and perceived value of native versus introduced plants is not well understood.
Alicia Rihn, Ariana P. Torres, Sue Barton, Bridget K. Behe   +3 more
wiley   +1 more source