Results 91 to 100 of about 1,220,485 (237)

Mosaic DICER1 RNase IIIb hotspot mutation with multiple tumors: case report and literature review

Frontiers in Oncology
We present a case of a 6-month-old boy who was diagnosed with Peutz–Jeghers polyps, intestine fusiform mesenchymal tumor, Wilms tumor, and Ir type pleuropulmonary blastoma (PPB) successively, with mosaic DICER1 RNase IIIb hotspot mutation: c.5113G>A p.
Peiyi Yang, Mei Jin, Wen Zhao, Chao Duan, Jie Yu, Yanchao Qu, Libing Fu, Tong Yu, Xiaoman Wang, Ruolan Guo, Chunying Cui, Dong Mei, Yan Su   +12 more
doaj   +1 more source

Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression

Cell Proliferation, EarlyView.
Wt1 expressed in the MD mesenchyme promotes MD regression by inducing Wif1 and Osx transcription. In male mice, mesenchyme‐specific inactivation of Wt1 results in MD retention. ABSTRACT In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development.
Min Chen, Xin Qi, Shanshan Qin, Jia Kang, Changhuo Cen, Miao Guo, Yang Gao, Mengyue Wang, Jiayi Li, Xiuhong Cui, Yanbo Wang, Lan Zhu, Fei Gao   +12 more
wiley   +1 more source

HMGA2 is a highly sensitive marker for DICER1‐related tumours

Histopathology, EarlyView.
Aims DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1‐related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent‐onset tumours.
Paul S. Thorner, Anne‐Laure Chong, Naciba Benlimane, Lili Fu, Marc R. Fabian, William D. Foulkes   +5 more
wiley   +1 more source

Rare case of primary bladder Wilm's tumor in a 1-year old boy

Urology Case Reports, 2019
Extrarenal Wilms' tumor (EWRT) is a rare entity, but primary bladder Wilm's tumor is even rarer with only 1 case reported. A 1-year old boy came with chronic urinary retention.
Jufriady Ismy, Jufitriani Ismy, Reno Kamarlis, Akhmad Mustafa   +3 more
doaj   +1 more source

Patient‐Derived Organoids and High‐Throughput Drug Screening: Advancing Functional Precision Medicine in Pediatric Cancer

Organ Medicine, EarlyView.
Yiyang Bao, Xingfei Chen, Jingyi Huang, Xiaoyu Lin, Yanlai Tang   +4 more
wiley   +1 more source

WTAP‐mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy

Journal of Diabetes Investigation, EarlyView.
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen   +6 more
wiley   +1 more source

Bilateral Wilms Tumor - Case Report of a Patient with Family History [PDF]

Oliwia Rdzanek,1 Patrycja Najda,1 Karolina Parysek-Wójcik,2 Anna Pytlik,2 Monika Lejman,3 Joanna Zawitkowska4 1Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland ...
Pytlik A, Zawitkowska J, Najda P, Rdzanek O, Lejman M, Parysek-Wójcik K   +5 more
core  

External Beam Radiation Therapy for Wilms Tumor [PDF]

, 2022
This project explains Wilms tumor cancer and the role radiation therapy can play in treating patients who have the disease. General statistics, symptoms, cancer severity, contributing factors, imaging options, and treatment options are also discussed ...
Galdi, Alyssa
core  

Horseshoe kidney with teratoid type of Wilms tumor: a rare case report

BMC Nephrology
Background Horseshoe kidney is the most common renal fusion anomaly, and Wilms tumor is the most frequent renal malignancy in children. The occurrence of Wilms tumor in association with horseshoe kidney is a scarce anomaly.
Nafiseh Mortazavi, Alireza Eshghi, Ardalan Ahmadvand, Gholamreza Bahoush, Parnian Ahmadvand, Ali Ghasemi, Kazem Ghaffari   +6 more
doaj   +1 more source

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li, Hongmei Liu, Yu Mao, Huanhuan Wang, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source