Results 81 to 90 of about 29,255 (243)

Kidney: Nephroblastoma (Wilms tumor) [PDF]

, 2007
Review on Kidney: Nephroblastoma (Wilms tumor), with data on clinics, and the genes ...
Erson, AE, Petty, EM
core   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Fetal programming and Wilms tumor [PDF]

, 2019
BACKGROUND: The "fetal programming" hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth ...
Heck, Julia E, He, Di, Hansen, Johnni, Olsen, Jorn, Janzen, Carla, Federman, Noah, Ritz, Beate   +6 more
core   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Case Report: Autosomal dominant polycystic kidney disease and Wilms’ tumor in infancy and childhood

Frontiers in Pediatrics
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is rare but one of the most common inherited kidney diseases. Normal kidney function is maintained until adulthood in most patients.
Doviltyte Zina, Doviltyte Zina, Kiudeliene Rosita, Kiudeliene Rosita, Zviniene Kristina, Zviniene Kristina, Rutkauskiene Giedre, Rutkauskiene Giedre, Masalskiene Jurate, Masalskiene Jurate   +9 more
doaj   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study

BMC Cancer
Background Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the susceptibility to develop certain tumor
Wen Fu, Linqing Deng, Xiaosong Yan, Rui-Xi Hua, Jiao Zhang, Haixia Zhou, Changmi Deng, Suhong Li, Jiwen Cheng, Jichen Ruan, Jing He, Guochang Liu   +11 more
doaj   +1 more source

Evaluation of Metanephrine and Lactate Dehydrogenase in Pediatric Wilms Tumor and Neuroblastom

مجلة كلية الطب
Background: Wilms' tumor and Neuroblastoma are common pediatric malignancies, with biochemical markers like plasma metanephrines and serum lactate dehydrogenase (LDH) being studied for diagnostic and prognostic values.
Nihad A. Jwda, Manal K. Rasheed , Hasanein H.Ghali   +2 more
doaj   +1 more source

A Pathologic Link between Wilms Tumor Suppressor Gene, WT1, and IFI16

Neoplasia: An International Journal for Oncology Research, 2008
The Wilms tumor gene (WT1) is mutated or deleted in patients with heredofamilial syndromes associated with the development of Wilms tumors, but is infrequently mutated in sporadic Wilms tumors.
Marianne K-H. Kim, Jacqueline M. Mason, Chi-Ming Li, Windy Berkofsky-Fessler, Le Jiang, Divaker Choubey, Paul E. Grundy, Benjamin Tycko, Jonathan D. Licht   +8 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source