Results 41 to 50 of about 47,086 (236)
Expression and prognostic value of Wilms' tumor 1 and early growth response 1 proteins in nephroblastoma [PDF]
, 2000 Wilms' tumor is one of the most common solid tumors of children. The protein product of the tumor-suppressor gene, Wilms' tumor 1 (WT-1), binds to the same DNA sequences as the protein product of the early growth response
Ghanem, M.A.I. (Mazen) +9 more
core
METTL3 regulates WTAP protein homeostasis [PDF]
, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
core +2 more sources
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review [PDF]
, 2020 Cell-free DNA profiling using patient blood is emerging as a non-invasive complementary technique for cancer genomic characterization. Since these liquid biopsies will soon be integrated into clinical trial protocols for pediatric cancer treatment ...
Astrahantseff, Kathy +12 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt +76 more
wiley +1 more source
A big Wilms tumor in a 14-months-old boy
Journal of Education, Health and Sport, 2019 Introduction. Wilms tumor (nephroblastoma) is a malignant neoplasm located in a kidney. It is typical for children and it occurs almost exclusively in a childhood. Purpose of work, material and methods. The aim of the study is presentation of symptoms,
Agnieszka Wójtowicz +3 more
doaj +3 more sources
Wilms\u27 Tumor and Neuroblastom: Results of Therapy [PDF]
, 1973 Wilms\u27 tumor and neuroblastoma are numerically among the most common noncerebral malignant solid tumors in children.
Maurer, Harold M.
core +1 more source
Cancer, 1984 A child with bilateral Wilms' tumors is reported. The left renal tumor showed nephroblastoma with several tissues of apparent mesenchymal derivation and tubules with diverse epithelial differentiation. The right-sided tumor showed the more familiar triphasic pattern of nephroblastoma.
Sadick Variend +3 more
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: As an epigenetic alteration, DNA methylation plays an important role in early Wilms tumorigenesis and is possibly used as marker to improve the diagnosis and classification of tumor heterogeneity.Methods: Methylation data, RNA-sequencing (RNA-
Fucai Tang +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source