Results 61 to 70 of about 3,009,060 (331)

Teratoid Wilms' tumor [PDF]

Cancer, 1984
A child with bilateral Wilms' tumors is reported. The left renal tumor showed nephroblastoma with several tissues of apparent mesenchymal derivation and tubules with diverse epithelial differentiation. The right-sided tumor showed the more familiar triphasic pattern of nephroblastoma.
Sadick Variend, Richard D. Spicer, Lrcp Lond, Alan E. Mackinnon   +3 more
openaire   +2 more sources

A Children's Oncology Group and TARGET Initiative Exploring the Genetic Landscape of Wilms Tumor

Nature Genetics, 2017
We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing of 651 Wilms tumors.
S. Gadd, V. Huff, Amy L. Walz, A. Ooms, Amy E Armstrong, D. Gerhard, Malcolm A. Smith, J. G. Auvil, D. Meerzaman, Qingrong Chen, C. Hsu, Chunhua Yan, Cu Nguyen, Ying Hu, Leandro C. Hermida, Tanja Davidsen, Patee Gesuwan, Yussanne Ma, Zusheng Zong, A. Mungall, Richard A. Moore, M. Marra, J. Dome, C. Mullighan, Jing Ma, D. Wheeler, O. Hampton, Nicole Ross, J. Gastier-Foster, S. Arold, E. Perlman   +30 more
semanticscholar   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Update on Wilms tumor

Journal of Education, Health and Sport, 2023
Background: Wilms' tumor is the most common childhood renal neoplasm. Among the worst prognosis forms are the bilateral form. The symptom complex is non-specific for malignancy; the first symptoms may include hypertension.
Klaudia Kister, Jakub Laskowski, Paulina Bronst, Magdalena Mazur, Aleksandra Małolepsza, Monika Zach-Źródlak, Julia Czechowska, Lidia Rosa, Natalia Rektor, Anna Szabrańska   +9 more
doaj   +1 more source

Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

Nature Communications, 2019
The lack of model systems has limited the preclinical discovery and testing of therapies for Wilms tumor (WT) patients who have poor outcomes. Herein, we establish 45 heterotopic WT patient-derived xenografts (WTPDX) in CB17 scid-/- mice that capture the
A. Murphy, Xiang Chen, E. Pinto, Justin Williams, Michael R. Clay, S. Pounds, Xueyuan Cao, Lei Shi, Tong Lin, G. Neale, C. Morton, Mary A. Woolard, H. Mulder, H. Gil, J. Rehg, C. Billups, Matt L Harlow, J. Dome, P. Houghton, J. Easton, Jinghui Zhang, R. George, G. Zambetti, A. Davidoff   +23 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor.

JCI Insight, 2019
Wilms' tumor is the most common type of childhood kidney cancer. To improve risk stratification and identify novel therapeutic targets for patients with Wilms' tumor, we used high-resolution mass spectrometry proteomics to identify urine tumor markers ...
M. Ortiz, Saima Ahmed, Melissa Burns, A. Henssen, T. Hollmann, Ian C. MacArthur, S. Gunasekera, Lyvia Gaewsky, G. Bradwin, J. Ryan, A. Letai, Ying He, A. Naranjo, Yueh-Yun Chi, M. LaQuaglia, T. Heaton, P. Cifani, J. Dome, S. Gadd, E. Perlman, E. Mullen, H. Steen, A. Kentsis   +22 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

MIB-1 (KI-67) proliferation index and cyclin-dependent kinase inhibitor p27(Kip1) protein expression in nephroblastoma [PDF]

, 2004
PURPOSE: A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27(Kip1) expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the
Al-Doray, A.A., Ghanem, M.A.I. (Mazen), Heuvel-Eibrink, M.M. (Marry) van den, Kwast, Th.H. (Theo) van der, Mathoera, R.B. (Rejiv), Nijman, R.J.M. (Rien), Steenbrugge, G.J. (Gert Jan) van, Sudaryo, M.K.   +7 more
core  

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source