Results 91 to 100 of about 25,770 (285)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Provision of Ancillary Services with Variable Speed Wind Turbines [PDF]

, 2014
In recent years, the amount of wind turbines in the power system has increased tremendously. As the current wind turbines do not participate in the provision of ancillary services such as frequency control and voltage control, this may compromise the ...
De Kooning, Jeroen, Meersman, Bart, Van de Vyver, Jan, Vandevelde, Lieven, Vandoorn, Tine   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Optimization Strategy of Wind Power Curtailment Under LVRT Operation

IEEE Access
A novel wind power curtailment optimization method considering low-voltage ride through (LVRT) operation is developed. The reserve capacity of wind generation for reactive power output is necessary to ensure the proper operation of a wind power plant ...
Sangwon Kim
doaj   +1 more source

Flow-based nodal cost allocation in a heterogeneous highly renewable European electricity network

, 2018
For a cost efficient design of a future renewable European electricity system, the placement of renewable generation capacity will seek to exploit locations with good resource quality, that is for instance onshore wind in countries bordering the North ...
Greiner, Martin, Hörsch, Jonas, Schwenk-Nebbe, Leon J., Schäfer, Mirko, Tranberg, Bo   +4 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A Detailed Analysis of Long-Term Modelling Method of Power-to-Gas Hydrogen Generation Using Curtailed Wind Energy

Energies
Wind curtailment in Great Britain (GB) is increasing, leading to underutilisation of low-carbon energy and higher system costs. This paper develops a data-driven techno-economic framework for a hydrogen generation and storage system that converts ...
Abdussalam A. Aburziza, Mobin Naderi, Daniel T. Gladwin   +2 more
doaj   +1 more source

Equitable Distribution of Wind and Photovoltaic Power Curtailment

IFAC-PapersOnLine, 2018
Abstract Curtailment algorithm for renewable energy sources interconnected to a power grid has been developed so that the oversupply in the power grid could be prevented. The algorithm consists of the optimization problem the objective function of which is the equitable distribution of minimized curtailment.
D. Iioka, H. Saitoh
openaire   +1 more source