Results 141 to 150 of about 778,579 (363)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Examination of wind speed based on field measurements on a low-rise building
Frontiers in Built EnvironmentMean and peak wind speeds, as well as gust factors, integral scales, and intensity of turbulence values, are essential in formulating wind loading standards for structures.
Shuoqi Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
A model of a downburst, a wind tunnel program on planetary boundary layer, and airship in turbulence [PDF]
An engineering model of microbursts was developed as an aid to possible future flight simulation in wind shear.
Etkin, B.
core +1 more source
Wind Monitoring of the Saylorville and Red Rock Reservoir Bridges with Remote, Cellular-Based Notifications, May 2012 [PDF]
, 2012 Following high winds on January 24, 2006, at least five people claimed to have seen or felt the superstructure of the Saylorville Reservoir Bridge in central Iowa moving both vertically and laterally.
core
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Mapping global offshore wind resource: wake losses, optimisation potential and climate effects [PDF]
arXivIn this work, we assess global offshore wind energy resources, wake-induced losses, array layout optimisation potential and climate change impacts. We first map global offshore ambient wind resource from reanalysis data. We estimate wake-induced losses using an engineering wake model, revealing that locations with low (high) resource typically ...
arxiv
Deep Belief Networks Based Feature Generation and Regression for Predicting Wind Power [PDF]
arXiv, 2018 Wind energy forecasting helps to manage power production, and hence, reduces energy cost. Deep Neural Networks (DNN) mimics hierarchical learning in the human brain and thus possesses hierarchical, distributed, and multi-task learning capabilities. Based on aforementioned characteristics, we report Deep Belief Network (DBN) based forecast engine for ...
arxiv
Wind-tunnel measurements and comparison with flight of the boundary layer and heat transfer on a hollow cylinder at Mach 3 [PDF]
The wind tunnel tests were conducted both with and without boundary layer trips at Mach 3 and nominal free stream Reynolds numbers per meter ranging from 3.3 x 10 the 6th power.
Lamb, M., Stallings, R. L., Jr.
core +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source