Results 161 to 170 of about 778,579 (363)
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Recent and Current Wind Engineering Research at the National Institute of Standards and Technology. [PDF]
J Struct Eng (N Y N Y), 2018 Duthinh D +8 more
europepmc +1 more source
The Mod-2 wind turbine development project [PDF]
A major phase of the Federal Wind Energy Program, the Mod-2 wind turbine, a second-generation machine developed by the Boeing Engineering and Construction Co. for the U.S. Department of Energy and the Lewis Research Center of the National Aeronautics and
Dennett, J. T. +2 more
core +1 more source
Analysis and validation of CFD wind farm models in complex terrain. Effects induced by topography and wind turbines [PDF]
, 2010 Wind farms have been extensively simulated through engineering models for the estimation of wind speed and power deficits inside wind farms. These models were designed initially for a few wind turbines located in flat terrain.
Barthelmie, Rebecca J. +2 more
core
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
Proceedings, 15th International Conference on Wind Engineering (ICWE 15), 2019 The author maintains that an adequate education in a discipline as vast and articulated as wind engineering cannot fail to recognize first its origins, developments, fundamentals, advancements and prospects. In this context, an analysis of the actual state of education should identify its limits, gaps and strengths, as well as the hard core of ...
openaire +1 more source
FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source