Results 21 to 30 of about 49,771 (264)

Vulnerability and Robustness of Civil Infrastructure Systems to Hurricanes

open access: yesFrontiers in Built Environment, 2017
Civil infrastructure systems play an important role in community resilience. Without proper functioning of the infrastructure, especially power delivery, society will not recover quickly from disruptive events, such as hurricanes.
Shuoqi Wang, Dorothy A. Reed
doaj   +1 more source

The Multipurpose New Wind Tunnel STU

open access: yesCivil and Environmental Engineering, 2014
BLWT STU tunnel, which is currently in test mode, will in its two measuring sections allow to prepare measurements with laminar and turbulent wind flow.
Hubová Oľga, Lobotka Peter
doaj   +1 more source

Study on the Wake of a Miniature Wind Turbine Using the Reynolds Stress Model

open access: yesEnergies, 2016
The Reynolds Stress Model (RSM) is adopted to simulate the wind turbine wake and the simulation results are compared with the wind tunnel test data, simulation results from the standard k-ε model and a modified k-ε model.
Jianxiao Hu, Qingshan Yang, Jian Zhang
doaj   +1 more source

Engineering-Based Tornado Damage Assessment: Numerical Tool for Assessing Tornado Vulnerability of Residential Structures

open access: yesFrontiers in Built Environment, 2020
Following a series of deadly tornadoes between 2011 and 2013, this paper develops a numerical tool to help communities better predict and quantify the potential tornado damage to single-family residential structures from a tornado strike.
Anant Jain   +3 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Aerodynamic mitigation of low-rise building with complex roof geometry

open access: yesFrontiers in Built Environment, 2023
During strong wind events, building roofs are subjected to high wind uplift forces (suctions), which often lead to severe roofing component damage, or even roof total failure, flying debris, and water intrusion, hence, interior damages.
Raghdah Al-Chalabi, Ahmed Elshaer
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Wind Vulnerability of Flexible Outdoor Single-Post Billboards

open access: yesApplied Sciences, 2023
Increased temperature due to global climate change is increasing the magnitude and frequency of extreme winds making billboard structures more vulnerable.
Rolando Salgado-Estrada   +7 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

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