Results 31 to 40 of about 49,771 (264)

Experimental study on wind load characteristics of sloped roof photovoltaic array

Advances in Mechanical Engineering
Wind load is a critical factor that threatens the structural safety of rooftop PV systems. Experimental tests in a wind tunnel investigated the impact of wind direction and roof slopes ranging from 15° to 60° on the wind loads experienced by PV arrays ...
Hailong Yan, Qiuyin Wang, Changzhao Qian, Jianjiang Chen, Renhao Zeng   +4 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Unsteady Aerodynamics of Bridge Decks in Transient Winds: Vortex Memory Effects and Path-Dependent Responses

Advances in Civil Engineering
This study unveils novel vortex memory mechanisms governing unsteady aerodynamics of streamlined bridge decks under transient winds via CFD simulation with the SST k-ω model (the acceleration magnitudes were set as ±5 m/s2 and ±10 m/s2, respectively ...
Wang Tang, Qiuhua Chen
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Analysis of Extreme Wind Pressure Based on Extreme Value Distribution Theory

Atmosphere
When extreme wind pressure is predicted based on the extreme value distribution theory, the sampling time–distance and sample volume of wind pressure data are important influencing factors. To discuss and analyze the influence of time–distance and sample
Weihu Chen, Yuji Tian, Fan Bai
doaj   +1 more source

Wind tunnel tests of tent halls of different shape

MATEC Web of Conferences, 2017
Aerodynamic investigations of wind pressure distribution on the surfaces of models of tent halls were carried out in the boundary layer wind tunnel at the Cracow University of Technology.
Porowska Agnieszka, Kłaput Renata, Flaga Andrzej   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Flow characteristics over NACA4412 airfoil at low Reynolds number

EPJ Web of Conferences, 2016
In this study, the flow phenomena over NACA4412 were experimentally observed at various angle of attack and Reynolds number of 25000, 50000 and 75000, respectively.
Genç Mustafa Serdar, Koca Kemal, Açıkel Halil Hakan, Özkan Gökhan, Kırış Mehmet Sadık, Yıldız Rahime   +5 more
doaj   +1 more source