Results 111 to 120 of about 1,027,351 (297)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Applied SciencesMaintaining stable operation and maximum power extraction in wind turbines under significant wind speed variations remains a key challenge in wind energy systems.
Cristian Paul Chioncel +2 more
doaj +1 more source
POWER CONDITIONING UNIT FOR SMALL SCALE HYBRID PV-WIND GENERATION SYSTEM [PDF]
, 2011 Small-scale renewable energy systems are becoming increasingly popular due to soaring fuel prices and due to technological advancements which reduce the cost of manufacturing.
AHMED-MAHMOUD, ASHRAF
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Select Committee on Wind Turbines final report [PDF]
, 2015 The committee recommends the Commonwealth Government create an Independent Expert Scientific Committee on Industrial Sound responsible for providing research and advice to the Minister for the Environment on the impact on human health of audible noise ...
Select Committee on Wind Turbines
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Axial flux PM coreless stator machine development for low speed wind generator
, 2017 Developing nations' rural populations need small electrical power sources for battery energy storage. Development of a micro-wind generation permanent magnet generator with no or low cogging torque would be a major advancement for low wind speed areas ...
Kaliyev, Vladislav +5 more
core +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source