Results 91 to 100 of about 1,027,351 (297)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genetic algorithm optimization for pitch angle control of variable speed wind turbines

MATEC Web of Conferences, 2017
In the article, the problem of optimization of the control law for rotating the blades of a wind generator with the purpose of increasing its output power is considered. The dynamics of a wind generator can be described by a nonlinear mathematical model,
Burakov Mikhail, Shishlakov Vladislav
doaj   +1 more source

Coordinated Control Strategies for a Permanent Magnet Synchronous Generator Based Wind Energy Conversion System

Energies, 2017
In this paper, a novel co-ordinated hybrid maximum power point tracking (MPPT)-pitch angle based on a radial basis function network (RBFN) is proposed for a variable speed variable pitch wind turbine.
Ramji Tiwari, Sanjeevikumar Padmanaban, Ramesh Babu Neelakandan   +2 more
doaj   +1 more source

Wind-Generated Current and Phase Speed of Wind Waves

Journal of Physical Oceanography, 1972
Measurements of drift were made in a wind and wave facility at different elevations below the mean water level. The drift profiles were obtained for reference wind speeds, Ur = 3.1, 5.7 and 9.6 m/sec. The measurement technique involved tracing the movement of small paper discs which were soaked in water to become neutrally buoyant at the elevation of ...
openaire   +2 more sources

Battery sizing for a stand alone passive wind system using statistical techniques [PDF]

, 2011
In this paper, an original optimization method to jointly determine a reduced study term and an optimum battery sizing is investigated. This storage device is used to connect a passive wind turbine system with a stand alone network. A Weibull probability
Belhadj, Jamel, Sareni, Bruno, Roboam, Xavier, J Belhadj, X Roboam, B Sareni, M Belouda, Belouda, Malek   +7 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

System-wide inertial response from fixed speed and variable speed wind turbines [PDF]

, 2011
IEEE PES 2011 General Meeting, Detroit, Michigan, USA, July 24-28, 2011As wind penetration levels on power systems increase worldwide, the dynamic characteristics of these systems are changing due to the displacement of synchronous generation. One issue,
Lisa Ruttledge, Ruttledge, Lisa, Flynn, Damian, Damian Flynn   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Rotor angle stability with high penetrations of wind generation [PDF]

, 2012
This paper explores the relationship between wind generation, particularly the control of reactive power from variable speed wind turbine generators, and the rotor angle stability of the conventional synchronous generators in the system.
O\u27Malley, Mark, Andrew Keane, O'Malley, Mark, Mark O'Malley, Vittal, Eknath, Keane, Andrew, Eknath Vittal   +6 more
core   +1 more source