Results 141 to 150 of about 39,461 (310)

A study of the statistical approach to wind loading

, 1975
Includes bibliographical references.This study is concerned with the prediction of the maximum probable response of structures in the along-wind direction.
Watson, Bjorn Hugh Henry
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Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Gust response: a validation experiment and preliminary numerical simulations

, 2011
In this paper the experimental setup and first results for a gust generator experiment will be presented. The experiment was carried out in the transonic wind-tunnel facility in Goettingen (DNW-TWG).
Hennings, Holger, Neumann, Jens, Mai, Holger   +2 more
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Inertial response from wind turbines: the impact on structural loads [PDF]

, 2012
This works evaluates the impact on structural loads of DFIG wind turbines providing inertial response while operating at rated power. The approach is to use an integrated simulation environment to model the most important electrical, structural, and ...
Cutululis, Nicolaos Antonio, Barahona Garzon, Braulio, Hansen, Anca Daniela, Sørensen, Poul Ejnar   +3 more
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

An analytical model for along wind design wind load of tall buildings

, 2013
An analytical model for tall buildings’ alongwind Equivalent Static Wind Loads is proposed. The basic assumptions, procedures and the parameters used in this model are mainly based on the results of wind tunnel investigation.
Cheng, Chii-Ming; Tsai, Ming-Shu; Lo, Yuan-Lung
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Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Model Fidelity Study of Dynamic Transient Loads in a Wind Turbine Gearbox: Preprint [PDF]

, 2013
Transient events cause high loads in the drivetrain components so measuring and calculating these loads can improve confidence in drivetrain design.
Keller, J., Guo, Y., Xing, Y., Moan, T.
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