Results 121 to 130 of about 39,461 (310)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Wind, wave and sea current loads on offshore wind turbines [PDF]
This study investigated coupling features of wind, wave and tidal current loads and their combined effects on thestructural response of a bottom-fixed monopole supported offshore wind-turbine.
Buljac A, Yang W, Kozmar H, Kareem A
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Vertical-axis wind turbines in oblique flow: sensitivity to rotor geometry
, 2011 Increasing interest is being shown worldwide in the application of vertical-axis wind turbines for decentralised electricity generation within cities.
Scheurich, Frank, Brown, Richard
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Reduction of fatigue loads on wind energy converters by advanced control methods
, 2022 4 S. : Ill., Lit.With the increasing size of wind energy converters fatigue loads and extreme loads are becoming more and more crucial for the constructive design.
Krüger, T. +5 more
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Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 2010 Numerical simulations of the NREL phase VI wind turbine operating in yawed conditions have been performed using two computational methods; one based on the solution of the Reynolds-averaged Navier-Stokes equations (RANS) using unstructured overset meshes
Fletcher, Timothy M. +5 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source