Results 111 to 120 of about 39,461 (310)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Dynamic analysis of road vehicle-bridge systems under turbulent wind by means of Finite Element Models

, 2011
When an automobile passes over a bridge dynamic effects are produced in vehicle and structure. In addition, the bridge itself moves when exposed to the wind inducing dynamic effects on the vehicle that have to be considered.
Goicolea Ruigómez, José María, Oliva Quecedo, Javier, Astiz Suárez, Miguel Angel, Antolin Sanchez, Pablo   +3 more
core  

Surrogate Models for Wind Turbine Electrical Power and Fatigue Loads in Wind Farm

, 2020
Fatigue damage of turbine components is typically computed by running a rain-flow counting algorithm on the load signals of the components. This process is not linear and time consuming, thus, it is non-trivial for an application of wind farm control ...
Lio, Wai Hou, Wai Hou Lio, Meng, Fanzhong, Georgios Gasparis, Fanzhong Meng, Gasparis, Georgios   +5 more
core   +1 more source

Experimental Study on Wind Load of Large-Span Flexible Photovoltaic Structure Considering Different Tilt Angles

Energies
Due to their light weight, low stiffness, and large range of tilt angle changes, flexible-support photovoltaic structures are highly sensitive to wind loads.
Bin Zhang, Shidong Nie, Min Liu, Honghao Zhang, Yifan Wang, Xinling Fan, Dongdong Zhang, Huaizhong Huang   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of wind flow direction on the loads at wind farm [PDF]

, 2019
This paper investigates the effect of wind flow direction on the fatigue loads on wind turbine within a wind farm, to determine the most critically loaded machines within the wind farm. The fatigue loads are calculated according IEC standards.
Kazacoks, Romans, Leithead, William, Amos, Lindsey Joanne   +2 more
core  

Transmission line ice accretion and wind loads modelling

, 2023
It is imperative to model the ice and wind loads on transmission lines to understand when failures are likely to occur to avoid significant economic losses and electricity supply instabilities.
Aghamohammadi, Mehrdad, Lock, Nick, Turner, Richard, Smith, Daniel, Flay, Richard   +4 more
core  

Field measurements of wind-induced transmission tower foundation loads

, 2020
This paper discusses some of the findings arising from long-term monitoring of the wind effects on a transmission tower located on an exposed site in South-West England.
Toy, N, Parke, GAR, Disney, P, Savory, E, Zeinoddini, M   +4 more
core   +1 more source