Results 71 to 80 of about 3,828,803 (394)

CFD and aeroelastic analysis of the MEXICO wind turbine [PDF]

, 2014
This paper presents an aerodynamic and aeroelastic analysis of the MEXICO wind turbine, using the compressible HMB solver of Liverpool. The aeroelasticity of the blade, as well as the effect of a low-Mach scheme were studied for the zero-yaw 15m/s wind ...
Barakos, G., Carrión, M., Gómez-Iradi, S., Munduate, X., Steijl, R., Woodgate, M.   +5 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Mass-loading of pulsar winds [PDF]

Monthly Notices of the Royal Astronomical Society, 2003
24 pages, 4 ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

High Specification Offshore Blades: Work Package: 1B: Blades Design [PDF]

, 2008
This report outlines the current state of the art in offshore wind turbine blade aerodynamic design, along with the key technical limitations and possible technologies which may improve the aerodynamic design of blades and turbine rotors in the future ...
Brown, Richard, Fletcher, Timothy, Galbraith, Roderick, York, Christopher   +3 more
core  

Assessment and calibration of the γ equation transition model for a wide range of Reynolds numbers at low Mach [PDF]

, 2017
The numerical simulation of flows over large-scale wind turbine blades without considering the transition from laminar to fully turbulent flow may result in incorrect estimates of the blade loads and performance.
Barakos, George, Colonia, Simone, Leble, Vladimir, Steijl, Rene   +3 more
core   +1 more source

Estimation of wind loads on a tall building by an inverse method

, 2017
Many engineering applications require the knowledge of wind loads on structures. However, it is difficult or even impossible to measure these excitation forces from prototype structures directly.
L. Zhi, Mingxin Fang, Q.S. Li
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Wind-Load Calculation Program for Rectangular Buildings Based on Wind Tunnel Experimental Data for Preliminary Structural Designs

Buildings
In this study, we developed a wind load calculation program (WCP) capable of predicting wind loads with relative precision during the preliminary design phase.
Dong-Hyeon Shin, Young-Cheol Ha
doaj   +1 more source