Results 81 to 90 of about 39,461 (310)

Predicting wind turbine blade loads using vorticity transport and RANS methodologies [PDF]

, 2009
Two computational methods, one based on the solution of the vorticity transport equa- tion, and a second based on the solution of the Reynolds-Averaged Navier-Stokes equa- tions, have been used to simulate the aerodynamic performance of a horizontal ...
Brown, R.E., Kwon, O.J., Fletcher, T.M., Kim, R.E.   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Microtab dynamic modelling for wind turbine blade load rejection [PDF]

, 2014
A dynamic model characterising the effect of microtab deployment on the aerodynamics of its base aerofoil is presented. The developed model predicts the transient aerodynamic coefficients consistent with the experimental and computational data reported ...
Busawon, Krishna, Macquart, Terence, Maheri, Alireza   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Wind-Load Calculation Program for Rectangular Buildings Based on Wind Tunnel Experimental Data for Preliminary Structural Designs

Buildings
In this study, we developed a wind load calculation program (WCP) capable of predicting wind loads with relative precision during the preliminary design phase.
Dong-Hyeon Shin, Young-Cheol Ha
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Computational simulation of thunderstorm downbursts and associated wind turbine loads

, 2013
textWind turbines operate in a constantly changing wind environment. This requires modeling and simulation of extreme events in which the wind turbine operates and a study of associated turbine loads as part of the design practice and/or site assessment.
Pratapa, Phanisri Pradeep
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dynamic response of temporary structures due to wind loading

, 2015
Due to the lack of an international standard for the design of temporary stage structures, there have been several instances where temporary stage structures have failed and resulted in injury or death during strong wind events (Tomasetti, 2012).
Bishay, A. (x), Pagano, T., Kwok, Kenny C. S. (R14040), Dang, J. (x)   +3 more
core  

Identification of Wind Load Exerted on the Jacket Wind Turbines from Optimally Placed Strain Gauges Using C-Optimal Design and Mathematical Model Reduction

Journal of Marine Science and Engineering
Wind turbine towers experience complex dynamic loads during actual operation, and these loads are difficult to accurately predict in advance, which may lead to inaccurate structural fatigue and strength assessment during the structural design phase ...
Fan Zhu, Meng Zhang, Fuxuan Ma, Zhihua Li, Xianqiang Qu   +4 more
doaj   +1 more source