Results 81 to 90 of about 630,543 (304)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
2-Vinylanthraquinone-grafted XLPE suppresses AC electrical treeing by deep-trap regulation
Polymer TestingElectrical treeing is a primary degradation pathway in cross-linked polyethylene (XLPE) cable insulation, making enhancement of the tree-initiation voltage (TIV) critical for reliable high-voltage operation.
Ke Li +3 more
doaj +1 more source
Vertical wind profile characterization and identification of patterns based on a shape clustering algorithm [PDF]
, 2019 Wind power plants are becoming a generally accepted resource in the generation mix of many utilities. At the same time, the size and the power rating of individual wind turbines have increased considerably.
Bueso Sánchez, María del Carmen +4 more
core +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Wind Power Prediction Method Based on Long Short-term Memory Neural Network
发电技术, 2019 Wind power generation process has strong randomness, which leads to low accuracy of wind power prediction. In view of the above phenomenon, a wind power generation power prediction method based on deep learning algorithm was proposed.
Xiangjun LI, Gejian XU
doaj +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
IOSR Journal of Electrical and Electronics Engineering, 2013 The inability of Nigeria’s electricity power company (PHCN) to meet the demands of Nigerian consumers necessitates an aggressive search for alternative energy supply. There are many wind catchment sites at various locations in this country. In this paper the possibility of using wind power to feed isolated loads and/or being synchronized with the ...
openaire +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Influence of Virtual Synchronous Generators on Low Frequency Oscillations
CSEE Journal of Power and Energy Systems, 2022 Hui Liu +5 more
doaj +1 more source