Results 101 to 110 of about 2,638,880 (299)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Wind Speed Forecasting: A Comparative Study of Decomposition Techniques

ASEAN Journal on Science and Technology for Development
Renewable energy is sourced from natural resources that are continually available. Wind energy is a main category of renewable energy, which largely depends on wind speed.
Manisha Galphade, V.B. Nikam, Nilkamal More, Biplab Banerjee, Arvind W. Kiwelekar, Priyanka Sharma   +5 more
doaj   +1 more source

Stochastic analysis for wind speed forecasting [PDF]

, 2012
: The stability and availability required on the electrical power systems with wind sources are directly related to the accuracy of a short-term forecasting wind speed model.
Nemes, Ciprian, Tshibanda, Mbuyamba
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A Hybrid Wind Speed Forecasting System Based on a ‘Decomposition and Ensemble’ Strategy and Fuzzy Time Series

Energies, 2017
Accurate and stable wind speed forecasting is of critical importance in the wind power industry and has measurable influence on power-system management and the stability of market economics. However, most traditional wind speed forecasting models require
Hufang Yang, Zaiping Jiang, Haiyan Lu
doaj   +1 more source

Forecasting wind speed financial return

, 2013
The prediction of wind speed is very important when dealing with the production of energy through wind turbines. In this paper, we show a new nonparametric model, based on semi-Markov chains, to predict wind speed. Particularly we use an indexed semi-Markov model that has been shown to be able to reproduce accurately the statistical behavior of wind ...
D'AMICO, Guglielmo, Petroni F., Prattico F.   +2 more
openaire   +3 more sources

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

A unified forecasting model for solar irradiation and wind speed using ground-based data

Next Sustainability
The objective of this study is to realize short-term forecasting of time-varying solar irradiation and wind speed through a unified neural-network-based algorithm.
Arisa Masuda, Hana Hebishima, Shin-ichi Inage   +2 more
doaj   +1 more source