Results 91 to 100 of about 320,868 (280)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Novel Method of Estimating Iron Loss Equivalent Resistance of Laminated Core Winding at Various Frequencies

Energies
Electromagnetic and magnetic devices are increasingly prevalent in sectors such as transportation, industry, and renewable energy due to the ongoing electrification trend.
Maxime Colin, Thierry Boileau, Noureddine Takorabet, Stéphane Charmoille   +3 more
doaj   +1 more source

The Hyperbolic Heisenberg and Sigma Models in (1+1)-dimensions

, 1998
Hyperbolic versions of the integrable (1+1)-dimensional Heisenberg Ferromagnet and sigma models are discussed in the context of topological solutions classifiable by an integer `winding number'.
A. E. Winn, A. Kundu, A. Kundu, D. Lambert, H. Eichenherr, H. J. Vega de, J. H. Lee, J. P. Antoine, J. Tjon, L. A. Takhtadzhyan, L. A. Takhtajan, P. F. Drazin, P. O. Mazur, R. S. Ward   +13 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

DISTRIBUTED EXTERNAL SURFACE HARDENING OF CAR DESIGN BY WINDING

Nauka ta progres transportu, 2017
Purpose. The paper involves coverage of features and results of the research conducted by the authors to determine the feasibility and establishment of pre-stressed-strained state of freight cars by winding in order to improve their strength ...
O. V. Fomin, A. A. Stetsko, V. Y. Osmak
doaj   +1 more source

Winding number instability in the phase-turbulence regime of the Complex Ginzburg-Landau Equation

, 1996
We give a statistical characterization of states with nonzero winding number in the Phase Turbulence (PT) regime of the one-dimensional Complex Ginzburg-Landau equation.
B. Janiaud, B. Shraiman, D. Egolf, D. Egolf, E. Hernández-García, E. Hernández-García, E. Hernández-García, H. Chaté, H. Chaté, H. Chaté, H. Sakaguchi, H. Sakaguchi, J. Viñals, L. Pan, M. Cross, M. Cross, M. San Miguel, P. C. Hohenberg, P. Coullet, P. Kolodner, R. Montagne, R. Palmer, S. Wiggings, T. Kawahara, T. Leweke, W. van Saarloos, Y. Kuramoto   +26 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Winding Strings in AdS_3

, 2006
Correlation functions of one unit spectral flowed states in string theory on AdS_3 are considered. We present the modified Knizhnik-Zamolodchikov and null vector equations to be satisfied by amplitudes containing states in winding sector one and study ...
A. Zamolodchikov, A.B. Zamolodchikov, Carmen Núnez, D.M. Hofman, Estanislao Herscovich, G. Giribet, Pablo Minces, S. Ribault, T. Fukuda   +8 more
core   +1 more source