Results 31 to 40 of about 95,624 (289)

Redundant memory organization Patent [PDF]

open access: yes, 1967
Redundant memory for enhanced reliability of digital data processing ...
Vinal, A. W.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Multipolar SPM machines for direct drive application: a comprehensive design approach [PDF]

open access: yes, 2012
A closed-form, per-unit formulation is proposed, for the design of surface mounted permanent magnet motors with high number of poles. The model evaluates the shear stress, the power factor and the specific Joule loss as the indicators of the machine ...
Boazzo, Barbara   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A Fr\'{e}chet law and an Erd\"os-Philipp law for maximal cuspidal windings

open access: yes, 2012
In this paper we establish a Fr\'{e}chet law for maximal cuspidal windings of the geodesic flow on a Riemannian surface associated with an arbitrary finitely generated, essentially free Fuchsian group with parabolic elements. This result extends previous
Beardon   +14 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Magnetically advected winds [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society: Letters, 2017
Abstract Observations of X-ray absorption lines in magnetically driven disc winds around black hole binaries and active galactic nuclei yield a universal radial density profile ρ ∝ r−1.2 in the wind. This is in disagreement with the standard Blandford and Payne profile ρBP ∝ r−1.5 expected when the magnetic field is neither advected nor ...
Contopoulos, Ioannis   +2 more
openaire   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stepping motor control circuit Patent [PDF]

open access: yes, 1970
Stepping motor control apparatus exciting windings in proper time sequence to cause motor to rotate in either ...
Thornwall, J. C.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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