Results 51 to 60 of about 16,837,077 (292)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Does the View Affect the Price of an Apartment?

Real Estate Management and Valuation
The objective of the present study is to estimate the impact of the view from the apartment on the unit price using econometric methods. The present study was conducted on data from 2015-2024 relating to similar prefabricated buildings located in ...
Bas Marcin
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Impact of the Apartment’s Window Exposure to World Directions on Transaction Price

Real Estate Management and Valuation
The purpose of the study is to econometrically estimate the effect of the direction of window exposure on the unit price of housing. The research hypothesis according to which the exposure of windows to the east increases the unit price of apartments is ...
Bas Marcin
doaj   +1 more source

Window views psychological effects on indoor thermal perception: A comparison experiment based on virtual reality environments [PDF]

E3S Web of Conferences
Previous studies have indicated that window views significantly impact residents’ indoor thermal perception, but the exact pathways and extent of this cross-modal influence are not fully understood.
Wu Chunya, Yu Zhuoyu, Song Dexuan
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Influence of design elements on reaction to window views [PDF]

Urbanism. Arhitectura. Constructii
This article focuses on the respondents’ reactions to window views in dense urban environments. A representative sample of multistorey buildings in residential neighbourhoods in close-up window view was observed.
Živa Kristl, Martina Zbašnik-Senegačnik, Ajda Fošner   +2 more
doaj  

Devil in the Details – Visual Perception of the Landscape Features by Potential Residential Buyers

Real Estate Management and Valuation
It has long been established that people attach value to window views. However, the challenge in real estate market analyses is to capture what landscape features an attractive view contains and thus how they affect the worth (individual valuation) of ...
Pilarczyk Aleksandra, Kondak Anna, Grzelka Kornelia, Wiejak-Roy Grażyna, Bieda Agnieszka   +4 more
doaj   +1 more source