Results 101 to 110 of about 45,444 (266)

Observational evidence of the relationship between the tropical tropopause and tropical easterly jet streams over the Indian monsoon region

Atmospheric Science Letters
This paper presents the first quantitative relationship between the cold point tropopause (CPT) and tropical easterly jet (TEJ) using radiosonde observations over Gadanki (13.45° N, 79.2° E) during the Indian summer monsoon season 2006–2014.
Sanjay Kumar Mehta
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The Dissipation Regime of Turbulence on Mars Observed With Microphone Data From the Mars 2020 Perseverance Rover

Geophysical Research Letters
Turbulent winds are a regular occurrence in planetary boundary layers. Turbulence affects mixing, energy fluxes and forcing on the surface environment.
Alexander E. Stott, Naomi Murdoch, Martin Gillier, German Martinez, Tanguy Bertrand, Ralph Lorenz, Claire Newman, Ricardo Hueso, Manuel de la Torre Juárez, Donald Banfield, Sylvestre Maurice, Baptiste Chide, Jose Antonio Rodriguez Manfredi, David Mimoun   +13 more
doaj   +1 more source

Mass Loss in Be Stars: News from Two Fronts

Galaxies
Be stars are characterized by the presence of a circumstellar Keplerian disk formed from material ejected from the rapidly rotating stellar surface.
Alex C. Carciofi, Guilherme P. P. Bolzan, Pâmela R. Querido, Amanda C. Rubio, Jonathan Labadie-Bartz, Tajan H. de Amorim, Ariane C. Fonseca Silva, Vittória L. Schiavolim   +7 more
doaj   +1 more source

Rose of the winds: The order of winds

, 2022
In this proposal and inside the narrative framework of medieval fantasy history, the player will take the role of commander of the order of wind, which have to face the antagonist faction of the game called the dark tornado brotherhood. To fulfil this objective, the player will have to build and improve a military base to battle with the general of the
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

0.25 Deg Horizontal Winds and Derived Dynamic Quantities From NOAA‐20 and Suomi‐NPP Satellite Water Vapor Soundings

Geophysical Research Letters
We produced global 0.25° three‐dimensional distribution of horizontal wind vectors (or 3D winds) by tracking water vapor from the hyperspectral infrared sounders and microwave sounders aboard two polar satellites (NOAA‐20 and Suomi‐NPP) that have ...
A. Ouyed, X. Zeng, W. Wu, L. Lei, X. Liu, Y. Xu   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source