Results 111 to 120 of about 1,598,590 (349)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Massive stars in massive clusters - IV. Disruption of clouds by momentum-driven winds [PDF]

, 2013
We examine the effect of momentum-driven OB-star stellar winds on a parameter space of simulated turbulent giant molecular clouds using smoothed particle hydrodynamic simulations.
B. Ercolano, Banerjee, Bate, Benz, Bodenheimer, Capriotti, Carroll, Cunningham, Dale, Dale, Dale, Dale, Dale, Dale, Dale, Dib, Elmegreen, Elmegreen, Fierlinger, Franco, Freyer, Freyer, Hansen, Harper-Clark, Hunter, I. A. Bonnell, J. E. Dale, J. Ngoumou, Koo, Koo, Krumholz, Lada, Lamers, Larson, Lefloch, Li, Matzner, Matzner, Mazurek, McKee, Monaghan, Nakamura, Nakamura, Ostriker, Peters, Pittard, Rogers, Sandford, Sandford, Schneider, Smith, Tenorio-Tagle, Townsley, Townsley, Vázquez-Semadeni, Walch, Walch, Wang, Weaver, Weidner, Whitworth, Williams, Yorke   +62 more
core   +3 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ionization structure in the winds of B[e] supergiants: I. Ionization equilibrium calculations in a H plus He wind

, 2003
The non-spherically symmetric winds of B[e] supergiants are investigated. An empirical density distribution is chosen that accounts for the density concentrations and ratios derived from observations, and our model winds are assumed to contain only ...
Allen, Bjorkman, Castor, Cohen, Drew, Drew, Gummersbach, H. J. G. L. M. Lamers, Humphreys, Ignace, Kraus, Kurucz, Lamers, Lamers, Leitherer, M. Kraus, MacFarlane, Magalhães, McGregor, McGregor, Nota, Owocki, Owocki, Pauldrach, Pauldrach, Pelupessy, Schulte-Ladbeck, Seaton, Thum, Thum, Vink, Voors, Zickgraf, Zickgraf, Zickgraf, Zickgraf, Zickgraf   +36 more
core   +1 more source

Effect of the Coriolis Force on the Hydrodynamics of Colliding Wind Binaries [PDF]

, 2007
Using fully three-dimensional hydrodynamic simulations, we investigate the effect of the Coriolis force on the hydrodynamic and observable properties of colliding wind binary systems.
Cherepashchuk A. M., James M. Stone, M. Nicole Lemaster, Prilutskii O., Stevens I. R., Thomas A. Gardiner   +5 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The interaction of multiple stellar winds in stellar clusters: potential flow

, 2018
While several studies have investigated large-scale cluster winds resulting from an intra-cluster interaction of multiple stellar winds, as yet they have not provided details of the bordering flows inside a given cluster.
Fichtner, Horst, Kleimann, Jens, Noack, Alexander, Scherer, Klaus, Weis, Kertsin   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source