FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
The risk of hospitalization associated with foehn winds and temperature in the mountainous region of Switzerland. [PDF]
Environ EpidemiolSchneidewind T +3 more
europepmc +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Applying turbidity as a witness of the vulnerability of a ria to meteorological changes and anthropogenic interventions. [PDF]
Sci RepGonzález-Vidal N +2 more
europepmc +1 more source
This is a pre-print of a chapter for the Encyclopedia of Astrophysics (edited by I. Mandel, section editor F.R.N.
openaire +2 more sources
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Westerly winds impact glacier energy balance and sublimation at August-one glacier in northern Tibetan Plateau. [PDF]
iScienceGuo S, Li Y, Chen R, Liu J, Han C.
europepmc +1 more source
Turbulence statistics of H
Isabella A Gerrard +5 more
openalex +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Differential impacts of wind and waves on albatross flight performance in two ocean basins. [PDF]
Mov EcolMaywar IJ +5 more
europepmc +1 more source