Results 121 to 130 of about 6,315 (255)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Adaptive Collision Sensitivity for Efficient and Safe Human–Robot Collaboration

Advanced Intelligent Systems, EarlyView.
An adaptive collision‐sensitivity framework uses each robot link's effective mass to estimate contact forces online and decide when collaborative robots should stop or continue. Tested on simulated and real UR10e and simulated KUKA arms, it maintains conservative force estimates while reducing unnecessary stops and increasing task productivity. What is
Lukas Rustler, Matej Misar, Matej Hoffmann   +2 more
wiley   +1 more source

LLM‐Based Multimodal Robotic Endoscope Control Framework for Enhancing Human–Robot Interaction in Minimally Invasive Surgery

Advanced Intelligent Systems, EarlyView.
An large language model‐powered multimodal framework is developed for robotic endoscope control. It integrates speech recognition and real‐time instrument tracking, achieving 89.47% command accuracy with ~1s latency for natural human–robot interaction in minimally invasive surgery.
Yisen Huang, Wing Yin Ng, Qi Dou, Xixin Wu, Shannon Melissa Chan, Yunhui Liu, Philip Wai Yan Chiu, Zheng Li   +7 more
wiley   +1 more source

Basal Complex and Basal Venation of Odonata Wings: Structural Diversity and Potential Role in the Wing Deformation. [PDF]

PLoS One, 2016
Rajabi H, Ghoroubi N, Malaki M, Darvizeh A, Gorb SN.   +4 more
europepmc   +1 more source

Balancing Exploration and Exploitation Through a Sequential Hybrid of Roach Infestation and Mayfly Algorithms for Constrained Engineering Design Optimization

AI &Innovation, EarlyView.
ABSTRACT Maintaining an effective balance between exploration and exploitation is essential during optimization processes, from mathematical functions to more complex problems such as constrained engineering design optimization, particularly when addressing highly nonlinear issues with numerous local optima and strict feasibility requirements.
Enrique Lizárraga, Fevrier Valdez, Oscar Castillo, Patricia Melin   +3 more
wiley   +1 more source

Autonomic Nerve Fiber Compositions of Zygomaticotemporal and Lacrimal Nerves: A Cadaveric Immunohistochemical Analysis

International Forum of Allergy &Rhinology, EarlyView.
Key Points Zygomaticotemporal (ZTN) and lacrimal nerves (LN) both carried sympathetics and parasympathetics ZTNs had more parasympathetics than LNs, but markers varied significantly within and between nerves LN parasympathetics to the lacrimal gland may mitigate dry eye after vidian ...
Bushra Rahman, Hangil Lee, Kelly A. Shaftel, Abdurrahman Abdurrob, Yusra Mansour, Swapna Vemuri, Jun Jin, Jack P. Rock, John R. Craig   +8 more
wiley   +1 more source

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

Wing deformation improves aerodynamic performance of forward flight of bluebottle flies flying in a flight mill. [PDF]

J R Soc Interface
Hsu SJ, Deng H, Wang J, Dong H, Cheng B.
europepmc   +1 more source

Study on static aeroelasticity performance of high aspect ratio hybrid composite swept wings

Jixie qiangdu
ObjectiveTo address the geometric nonlinearity of high aspect ratio swept wings under aerodynamic loads, this study investigates the effects of carbon/glass fiber hybrid ratios and layup angles on bend-twist coupling deformation and aerodynamic ...
ZHANG Sheng, WANG Junli, LIU Jurong, ZHOU Yang, WANG Kangjie, WANG Jiahuan   +5 more
doaj  

A detailed redescription of a skeletally immature ‘Redondasaurus’ suggests ontogenetic transformations in the taxon mirror phytosaurian morphological evolution

The Anatomical Record, EarlyView.
Abstract The study of morphological evolution is fundamentally tied to ontogeny, yet studies of these heterochronic processes in the fossil record are rare. Fossils belonging to an ontogenetic series are difficult to assign to an ontogenetic stage due to inconsistent proxies for skeletal ages, challenging to taxonomically assign due to morphological ...
Erika R. Goldsmith, Michelle R. Stocker
wiley   +1 more source