Results 181 to 190 of about 173,899 (302)

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Replication of seizure-suppressing effects of alpha-linolenic acid on the <i>Drosophila melanogaster para ^Shudderer</i> mutant. [PDF]

MicroPubl Biol
Dinnel S, Weimer B, Davis A, Gerovac K, Hawbaker LM, Maser M, Shannon M, Brusich DJ.   +7 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Helicoverpa zea selected on Bt corn have wing shapes better suited to long distance flight. [PDF]

Environ Entomol
Mikac KM, Dominguez Davila JH, Powley MJ, Barclay S, Pezzini D, Reisig DD.   +5 more
europepmc   +1 more source

Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots

Advanced Science, EarlyView.
Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley   +1 more source

The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in <i>Drosophila</i> larvae. [PDF]

Proc Natl Acad Sci U S A
Suzawa M, McPherson WK, Dunham KE, Van Gorder EE, Reddy S, Jamali LA, Bland ML.   +6 more
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Five new species and three new country records of Megaspilidae from Xizang Autonomous Region, China (Hymenoptera, Ceraphronoidea). [PDF]

Zookeys
Wang X, Li F, Zhao WJ, Huang YX, Xiang CH, Chen HY, Zhu CD.   +6 more
europepmc   +1 more source

Programmable Multifunctional Bistable Structures for Energy Transfer and Dissipation

Advanced Science, EarlyView.
Utilizing the energy conversion characteristics of asymmetric bistable beams, this study develops a programmable multifunctional system composed of multiple bistable beams for energy transfer and dissipation. The high energy density enables the system to demonstrate potential in transient scenarios such as target delivery and shock absorption ...
Xin Na, Jincong Zhang, Zhicheng Chen, Venkatarao Selamneni, Haotian Chen, Hadi Heidari, Morteza Amjadi   +6 more
wiley   +1 more source

Quantitative modulation of a spatial enhancer through the biophysical properties of a transcription factor binding site. [PDF]

Sci Adv
Fallon C, Ling L, Cooper BH, Ceolin S, Chiu TP, Mitra R, Mühling B, Srinivasan V, Durmaz AD, Veselinovic D, Kothari M, Fylaktakis AP, Glassford WJ, Kribelbauer-Swietek JF, Papadopoulos DK, Mann RS, Rohs R, Gompel N.   +17 more
europepmc   +1 more source